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|Antigen||Programmed Cell Death 6 Interacting Protein (PDCD6IP) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus), Xenopus laevis Alternatives|
|Conjugate||This PDCD6IP antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|1 reference available|
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Product Details anti-PDCD6IP AntibodyTarget Details PDCD6IP Application Details Handling ProductDetails: References for anti-PDCD6IP antibody (ABIN181090) Images
|Specificity||This antibody recognises apoptotic-linked-gene-product 2 (ALG-2) interacting protein X (ALIX), a conserved adaptor protein which is ubiquitously expressed.|
|Characteristics||Synonyms: PDCD6-interacting protein, ALG-2-interacting protein 1, Hp95, KIAA1375, Programmed celldeath 6-interacting protein|
|Purification||Affinity Chromatography on Protein G|
|Immunogen||Alix fusion protein.|
Target Details PDCD6IPProduct Details anti-PDCD6IP Antibody Application Details Handling ProductDetails: References for anti-PDCD6IP antibody (ABIN181090) Images back to top
|Alternative Name||ALIX / PDCD6IP (PDCD6IP Antibody Abstract)|
|Background||ALIX was originally reported to play a role in apoptosis but has recently been shown to be involved in other cellular mechanisms including endosomal sorting, endocytosis, viral budding and actin cytoskeleton assembly. ALG2 interacting protein X is a Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. In case of infection, the HIV-1 virus directly takes advantage of its function for viral exocytosis and budding, via its interaction with HIV-1 p6 protein. It may play a role in the regulation of both apoptosis and cell proliferationSynonyms: ALG-2-interacting protein 1, Hp95, KIAA1375, PDCD6-interacting protein, Programmed cell death 6-interacting protein|
|Pathways||p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation|
Application DetailsProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Handling ProductDetails: References for anti-PDCD6IP antibody (ABIN181090) Images back to top
ELISA. Western Blot. Immunoprecipitation. Immunofluorescence. Immunohistochemistry on Paraffin Sections: This product does not require proteindigestion pre-treatment of paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details ProductDetails: References for anti-PDCD6IP antibody (ABIN181090) Images back to top
|Buffer||PBS, pH 7.4, 0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
ProductDetails: References for anti-PDCD6IP antibody (ABIN181090)Product Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details Handling Images back to top
Pan, Wang, Zhou, He, Koomen, Kobayashi, Sun, Corvera, Gallick, Kuang: "Involvement of the conserved adaptor protein Alix in actin cytoskeleton assembly." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34640-50, 2006
ImagesProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details Handling ProductDetails: References for anti-PDCD6IP antibody (ABIN181090) back to top