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Browse our anti-PIDD (PIDD) Antibodies

Full name:
anti-P53-Induced Death Domain Protein Antibodies (PIDD)
On are 35 P53-Induced Death Domain Protein (PIDD) Antibodies from 9 different suppliers available. A total of 39 PIDD products are currently listed.
1200011D09Rik, AU042446, Lrdd, Pidd
list all antibodies Gene Name GeneID UniProt
PIDD 57913 Q9ERV7
PIDD 55367 Q9HB75
PIDD 293625  

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Most Popular Reactivities for anti-PIDD (PIDD) Antibodies

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anti-Mouse (Murine) PIDD Antibodies:

anti-Human PIDD Antibodies:

anti-Rat (Rattus) PIDD Antibodies:

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Top referenced anti-PIDD Antibodies

  1. Human Polyclonal PIDD Primary Antibody for IP, IHC - ABIN1169268 : Tinel, Tschopp: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. in Science (New York, N.Y.) 2004 (PubMed)
    Show all 3 references for ABIN1169268

More Antibodies against PIDD Interaction Partners

Mouse (Murine) P53-Induced Death Domain Protein (PIDD) interaction partners

  1. The tumor-modulatory effects of Caspase-2 (show CASP2 Antibodies) and Pidd1 do not require the scaffold protein (show HOMER1 Antibodies) Raidd (show CRADD Antibodies)

  2. Loss of PIDD leads to an impaired inflammatory response after DNA damage.

  3. Caspase 2 (show CASP2 Antibodies) activity can be induced in neurons from PIDD-null mice, and NGF (show NGFB Antibodies) deprivation or Abeta (show APP Antibodies) use caspase 2 (show CASP2 Antibodies) and RAIDD (show CRADD Antibodies) to execute death of these neurons.

  4. P450 (show POR Antibodies) levels were higher in female DES (show DES Antibodies)-treated p53 (show TP53 Antibodies)+/- mice compared to treated wild type mice.

  5. Results suggest that at least one alternative PIDDosome-independent mechanism of caspase-2 (show CASP2 Antibodies) activation exists in mammals in response to DNA damage.

  6. PIDD does not play an essential role for all p53 (show TP53 Antibodies)-mediated or p53 (show TP53 Antibodies)-independent apoptotic pathways.

Human P53-Induced Death Domain Protein (PIDD) interaction partners

  1. By sequestering PIDD at the kinetochore, BubR1 (show BUB1B Antibodies) acts to delay PIDDosome formation until the next cycle, defining a new mechanism by which cells evade apoptosis during mitosis.

  2. The ATM (show ATM Antibodies) phosphorylation of the PIDD DD enables a binary switch through which cells elect to survive or die upon DNA injury.

  3. PIDD performs key functions upon UV irradiation, including TLS (show FUS Antibodies), NHEJ, NF-kappaB (show NFKB1 Antibodies) activation and cell death.

  4. Hsp90 (show HSP90 Antibodies) has a major role in controlling PIDD functional activity.

  5. a new splicing variant of PIDD named PIDD4 is reported.

  6. point mutations on RAIDD (show CRADD Antibodies) (R147E) and on PIDD (Y814A) exert a dominant negative effect on the formation of the PIDDosome, and that this effect cannot be applied after the PIDDosome has been formed

  7. Total caspase-2 (show CASP2 Antibodies) is upregulated during tumour progression in renal cell carcinomas.

  8. activation of caspase-2 (show CASP2 Antibodies) occurs in a complex that contains PIDD, whose expression is induced by p53 (show TP53 Antibodies), and RAIDD (show CRADD Antibodies); increased PIDD expression resulted in spontaneous activation of caspase-2 (show CASP2 Antibodies) and sensitization to apoptosis by genotoxic stimuli

  9. PIDD plays a critical role in DNA-damage-induced NF-kappaB (show NFKB1 Antibodies) activation, controlling the balance between life and death upon DNA damage.

  10. The functional consequences of the identified PIDD/nucleolin (show NCL Antibodies) interaction remain to be elucidated, but may be related to a recently discovered new role for PIDD in the activation of NF-kappaB (show NFKB1 Antibodies) upon genotoxic stress.

PIDD Antigen Profile

Antigen Summary

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with PIDD

  • leucine-rich and death domain containing (Lrdd) antibody
  • p53-induced death domain protein (PIDD) antibody
  • p53-induced death domain protein (Pidd) antibody
  • 1200011D09Rik antibody
  • AU042446 antibody
  • Lrdd antibody
  • Pidd antibody

Protein level used designations for PIDD

leucine-rich repeat and death domain-containing protein , p53 protein induced, with death domain , p53-induced protein with a death domain , leucine-rich repeats and death domain containing

57913 Mus musculus
55367 Homo sapiens
293625 Rattus norvegicus
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