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anti-Human RRM2B antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended RRM2B Antibody (supplied by: Log in to see )

Antigen
Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) Antibodies
  • MTDPS8A
  • MTDPS8B
  • P53R2
  • p53r2
  • p53R2
  • RRM2B
Epitope
AA 2-17, N-Term
17
16
15
12
10
3
3
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
84
36
34
2
1
Host
Rabbit
79
5
Clonality
Polyclonal
Conjugate
This RRM2B antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
65
40
16
11
10
7
4
1
1
Supplier
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Catalog No. ABIN500437
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.3457523 ABIN2649402 IHC (p) Rabbit Log in to see
0.00089485606 ABIN214469 IHC (p) WB Rabbit AA 2-17 Log in to see Polyclonal
0.00089485606 ABIN303239 IHC (p) WB Rabbit AA 2-17 Log in to see Polyclonal
0.00089485606 ABIN1999943 IHC (p) ELISA WB Rabbit IgG AA 1-351 Log in to see Polyclonal
0.00089485606 ABIN1738967 IHC (p) WB Rabbit IgG AA 2-17 Log in to see Polyclonal
0.00089485606 ABIN755025 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal
0.00089485606 ABIN755032 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal
0.00089485606 ABIN755023 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.00089485606 ABIN2766790 IHC (p) WB Rabbit AA 2-17 Log in to see Polyclonal
0.00089485606 ABIN308797 IHC (p) IHC WB Rabbit AA 2-17 Log in to see Polyclonal

Top referenced anti-RRM2B antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-RRM2B Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 8 Antibodies 8 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 1 Antibodies
Immunofluorescence (IF) 2 Antibodies 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 6 Antibodies 8 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 6 Antibodies 6 Antibodies
Western Blotting (WB) 24 Antibodies 24 Antibodies

General

Antigen Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) Antibodies
Epitope AA 2-17, N-Term
(17), (16), (15), (12), (10), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(84), (36), (34), (2), (1)
Host Rabbit
(79), (5)
Clonality
Polyclonal
Conjugate This RRM2B antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(65), (40), (16), (11), (10), (7), (4), (1), (1)
Pubmed 4 references available
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Product Details anti-RRM2B Antibody

Target Details RRM2B Application Details Handling References for anti-RRM2B Antibody (ABIN500437) Images
Specificity This antibody detects p53R2 at N-term.
Purification Peptide Affinity Chromatography
Immunogen p53R2 antibody was raised against a synthetic peptide corresponding to amino acids 2 to 17 of human p53R2.
Isotype IgG

Target Details RRM2B

Product Details anti-RRM2B Antibody Application Details Handling References for anti-RRM2B Antibody (ABIN500437) Images back to top
Antigen
Alternative Name RRM2B / P53R2 (RRM2B Antibody Abstract)
Background The p53 tumor-suppresspr gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 , Chk2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase (1,7). p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression (8). p53R2 is an important target of p53 for tumour suppression.Synonyms: Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein
Gene ID 50484
UniProt Q7LG56
Pathways p53 Signaling

Application Details

Product Details anti-RRM2B Antibody Target Details RRM2B Handling References for anti-RRM2B Antibody (ABIN500437) Images back to top
Application Notes ELISA. Western blot: 0.5-1 μg/mL (A 39 kDa band can be detected). Immunohistochemistry on Paraffin Sections. Positive Controls: A431 Cell Lysate, 3T3 Whole Cell Lysate, Human Lung Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-RRM2B Antibody Target Details RRM2B Application Details References for anti-RRM2B Antibody (ABIN500437) Images back to top
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-RRM2B Antibody (ABIN500437)

Product Details anti-RRM2B Antibody Target Details RRM2B Application Details Handling Images back to top
Background publications

Tanaka, Arakawa, Yamaguchi, Shiraishi, Fukuda, Matsui, Takei, Nakamura: "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage." in: Nature, Vol. 404, Issue 6773, pp. 42-9, 2000

Oda, Ohki, Murasawa, Nemoto, Shibue, Yamashita, Tokino, Taniguchi, Tanaka: "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis." in: Science (New York, N.Y.), Vol. 288, Issue 5468, pp. 1053-8, 2000

Oda, Arakawa, Tanaka, Matsuda, Tanikawa, Mori, Nishimori, Tamai, Tokino, Nakamura, Taya: "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53." in: Cell, Vol. 102, Issue 6, pp. 849-62, 2000

Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998

Images

Product Details anti-RRM2B Antibody Target Details RRM2B Application Details Handling References for anti-RRM2B Antibody (ABIN500437) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-RRM2B antibody (Ribonucleotide Reductase M2 B (TP53 Inducible)) (AA 2-17) (ABIN500437) AP30640PU-N p53R2 antibody staining of Human lung tissue by Immunohistochemistry at 1...
Western Blotting (WB) image for anti-RRM2B antibody (Ribonucleotide Reductase M2 B (TP53 Inducible)) (AA 2-17) (ABIN500437) Western blot analysis of p53R2 expression in A431 cell lysate with this product at (A...