Browse our RRM2B Proteins (RRM2B)

Full name:
Ribonucleotide Reductase M2 B (TP53 Inducible) Proteins (RRM2B)
On are 6 Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) Proteins from 5 different suppliers available. Additionally we are shipping RRM2B Antibodies (86) and RRM2B Kits (2) and many more products for this protein. A total of 101 RRM2B products are currently listed.
list all proteins Gene Name GeneID UniProt
RRM2B 50484 Q7LG56
RRM2B 382985 Q6PEE3
Rat RRM2B RRM2B 299976  

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RRM2B Proteins (RRM2B) by Origin

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Top referenced RRM2B Proteins

  1. Human RRM2B Protein expressed in Escherichia coli (E. coli) - ABIN2005497 : Bourdon, Minai, Serre, Jais, Sarzi, Aubert, Chrétien, de Lonlay, Paquis-Flucklinger, Arakawa, Nakamura, Munnich, Rötig: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. in Nature genetics 2007 (PubMed)

More Proteins for RRM2B Interaction Partners

Human Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) interaction partners

  1. RRM1 (show RRM1 Proteins)/RRM2B enzyme is capable of retaining activity in hypoxia and therefore is favored over RRM1 (show RRM1 Proteins)/RRM2 (show RRM2 Proteins) in order to preserve ongoing replication and avoid the accumulation of DNA damage in hypoxic cells.

  2. p53R2 acts as a positive regulator of TrxR2 (show TXNRD2 Proteins) activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage

  3. Silencing of both PYCR1 (show PYCR1 Proteins) and PYCR2 (show PYCR2 Proteins) completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.

  4. A newly discovered role of E2F1 (show E2F1 Proteins) in the regulation of p53R2 expression in DNA damage response.

  5. analysis of caspase (show CASP3 Proteins)-dependent degradation of human R2 and p53R2 small subunits

  6. in Turkish population p53R2 genotype distributions between head and neck squamous epithelial cell cancer patients and control groups were not statistically significantly different.

  7. Data indicate that forkhead transcription factorsF OXO3 directly bound to and transcriptionally activated the promoter of ribonucleotide reductase subunit RRM2B, and induced the expression of RRM2B at RNA and protein levels.

  8. we found no support of the hypothesis that aberrations of RRM1 (show RRM1 Proteins) or RRM2B, neither individually nor in combination, are associated with an altered clinical outcome following chemotherapy.

  9. Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1 (show EGR1 Proteins)-mediated phosphatase and tensin homolog/Akt1 (show AKT1 Proteins) pathway in hepatocellular carcinoma.

  10. RRM2B expression may discriminate cervical cancer phenotype and radiochemotherapy outcome

Mouse (Murine) Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) interaction partners

  1. Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.

  2. Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.

RRM2B Protein Profile

Protein Summary

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with RRM2B

  • ribonucleotide reductase M2 B (TP53 inducible) (rrm2b)
  • ribonucleotide reductase M2 B (TP53 inducible) (RRM2B)
  • ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b)
  • MTDPS8A protein
  • MTDPS8B protein
  • p53R2 protein
  • RRM2B protein

Protein level used designations for RRM2B

ribonucleotide reductase M2 B (TP53 inducible) , ribonucleoside-diphosphate reductase subunit M2 B , TP53-inducible ribonucleotide reductase M2 B , p53-inducible ribonucleotide reductase small subunit 2 homolog , p53-inducible ribonucleotide reductase small subunit 2 short form beta , p53-inducible ribonucleotide reductase small subunit 2-like protein

379056 Xenopus laevis
420253 Gallus gallus
472832 Pan troglodytes
481988 Canis lupus familiaris
528960 Bos taurus
100062030 Equus caballus
100144925 Xenopus (Silurana) tropicalis
100172878 Pongo abelii
50484 Homo sapiens
382985 Mus musculus
299976 Rattus norvegicus
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