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Human RRM2B Protein expressed in Escherichia coli (E. coli) - ABIN2005497
Bourdon, Minai, Serre, Jais, Sarzi, Aubert, Chrétien, de Lonlay, Paquis-Flucklinger, Arakawa, Nakamura, Munnich, Rötig: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. in Nature genetics 2007
p53R2 acts as a positive regulator of TrxR2 (show TXNRD2 Proteins) activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage
Silencing of both PYCR1 (show PYCR1 Proteins) and PYCR2 (show PYCR2 Proteins) completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
A newly discovered role of E2F1 (show E2F1 Proteins) in the regulation of p53R2 expression in DNA damage response.
analysis of caspase (show CASP3 Proteins)-dependent degradation of human R2 and p53R2 small subunits
in Turkish population p53R2 genotype distributions between head and neck squamous epithelial cell cancer patients and control groups were not statistically significantly different.
Data indicate that forkhead transcription factorsF OXO3 directly bound to and transcriptionally activated the promoter of ribonucleotide reductase subunit RRM2B, and induced the expression of RRM2B at RNA and protein levels.
we found no support of the hypothesis that aberrations of RRM1 (show RRM1 Proteins) or RRM2B, neither individually nor in combination, are associated with an altered clinical outcome following chemotherapy.
Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1 (show EGR1 Proteins)-mediated phosphatase and tensin homolog/Akt1 (show AKT1 Proteins) pathway in hepatocellular carcinoma.
RRM2B expression may discriminate cervical cancer phenotype and radiochemotherapy outcome
RRM2B is highly induced in a p53 (show TP53 Proteins)-dependent manner during senescence and is expressed at higher levels in senescent precancerous human prostatic intraepithelial neoplasm lesions compared to adjacent normal prostate glands.
Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.
Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
ribonucleotide reductase M2 B (TP53 inducible)
, ribonucleoside-diphosphate reductase subunit M2 B
, TP53-inducible ribonucleotide reductase M2 B
, p53-inducible ribonucleotide reductase small subunit 2 homolog
, p53-inducible ribonucleotide reductase small subunit 2 short form beta
, p53-inducible ribonucleotide reductase small subunit 2-like protein