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Browse our anti-SERPINE1 (SERPINE1) Antibodies

Full name:
anti-serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Antibodies (SERPINE1)
On www.antibodies-online.com are 444 serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies from 32 different suppliers available. Additionally we are shipping SERPINE1 Proteins (152) and SERPINE1 Kits (115) and many more products for this protein. A total of 733 SERPINE1 products are currently listed.
Synonyms:
B230326M24Rik, HsT1201, PAI, PAI-1, PAI-2, Pai1, PAI1A, Pai1aa, PAI2, PI-7, PI7, Planh, Planh1, PLANH2, PN-1, RATPAI1A, SERPINE1, si:ch211-138a11.1, Spi4
list all antibodies Gene Name GeneID UniProt
SERPINE1 18787  
SERPINE1 5055 P05120
SERPINE1 24617 P20961

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Most Popular Reactivities for anti-SERPINE1 (SERPINE1) Antibodies

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anti-Mouse (Murine) SERPINE1 Antibodies:

anti-Human SERPINE1 Antibodies:

anti-Rat (Rattus) SERPINE1 Antibodies:

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Top referenced anti-SERPINE1 Antibodies

  1. Human Polyclonal SERPINE1 Primary Antibody for ELISA, ICC - ABIN446967 : Berard, Déglise, Alonso, Saucy, Meda, Bordenave, Corpataux, Haefliger: Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins. in Journal of vascular surgery 2013 (PubMed)
    Show all 8 references for ABIN446967

  2. Human Polyclonal SERPINE1 Primary Antibody for EIA, WB - ABIN954748 : Ma, Kwong, Tovar, Paek: Cyclic adenosine monophosphate induces plasminogen activator inhibitor-1 expression in human mast cells. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 4 references for ABIN954748

  3. Chicken Monoclonal SERPINE1 Primary Antibody for IF, WB - ABIN968717 : Bajou, Masson, Gerard, Schmitt, Albert, Praus, Lund, Frandsen, Brunner, Dano, Fusenig, Weidle, Carmeliet, Loskutoff, Collen, Carmeliet, Foidart, Noël: The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. in The Journal of cell biology 2001 (PubMed)
    Show all 3 references for ABIN968717

  4. Human Monoclonal SERPINE1 Primary Antibody for FACS, IHC - ABIN969566 : Oh, Olman, Benveniste: CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells. in Biological & pharmaceutical bulletin 2009 (PubMed)
    Show all 2 references for ABIN969566

  5. Human Polyclonal SERPINE1 Primary Antibody for IHC, ELISA - ABIN185384 : Baumruker, Csonga, Pursch, Pfeffer, Urtz, Sutton, Bofill-Cardona, Cooke, Prieschl: Activation of mast cells by incorporation of cholesterol into rafts. in International immunology 2003 (PubMed)
    Show all 2 references for ABIN185384

  6. Cow (Bovine) Polyclonal SERPINE1 Primary Antibody for IHC, WB - ABIN2782976 : Penco, Buscema, Patrosso, Marocchi, Grossi: New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. in BMC bioinformatics 2008 (PubMed)

  7. Dog (Canine) Polyclonal SERPINE1 Primary Antibody for EIA, IHC (p) - ABIN374547 : Keates, Tummala, Peek, Csizmadia, Kunzli, Becker, Correa, Romero-Gallo, Piazuelo, Sheth, Kelly, Robson, Keates: Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. in Infection and immunity 2008 (PubMed)

More Antibodies against SERPINE1 Interaction Partners

Xenopus laevis serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. The serpin PN1 (show SCN9A Antibodies) is a feedback regulator of FGF signaling in germ layer and primary axis formation.

Zebrafish serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. SERPINe1-derived 14-mer (show MERTK Antibodies) peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of viral haemorrhagic septicemia virus, but also of other fish rhabdoviruses.

  2. X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.

Mouse (Murine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. PAI-1 inhibitor PAI-039 prevents smooth muscle cell migration and neointimal hyperplasia.

  2. Tongqiaohuoxue decoction exerted an anti-thrombotic effect through the regulation of PAI-1 and fibrinolysis.

  3. PAI-1 plays a role in maintaining gastric mucosal organization in hypergastrinemia.

  4. Olmesartan did not significantly affect PAI1 levels in this mouse model

  5. BRD2 (show BRD2 Antibodies) is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein

  6. the involvement of PAI-1 in HIF-1 (show HIF1A Antibodies)-enhanced thrombosis and that an additional factor participates in regulating Pai-1 expression in compressed skin.

  7. Neutralization of the antifibrinolytic function of PAI-1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation.

  8. These results suggest the critical physiological role of TRL4-Fyn (show FYN Antibodies) interaction in the modulation of PAI-1-tPA (show PLAT Antibodies) axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries.

  9. aberrant Serpine2/Pn-1 (show SERPINE2 Antibodies) is required for proliferation of human and mouse medulloblastoma cells.

  10. PAI-1 can promote cell migration via LRP1 (show LRP1 Antibodies)-dependent activation of the beta-catenin (show CTNNB1 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) MAPK (show MAPK1 Antibodies) pathway

Human serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. We show that PAI-1 expression is significantly increased in the esophagi of patients with active eosinophilic esophagitis (EoE) compared with nondiseased esophagi and that EoE-directed therapy reduces the degree of PAI-1 expression. We further demonstrate that TGF-beta1 (show TGFB1 Antibodies) increases PAI-1 expression in primary human esophageal epithelial cells and fibroblasts from patients with EoE

  2. Higher plasma concentrations of a-2-AP and PAI-1 in patients with OSA indicated that these patients had increased prothrombotic activity. OSA increases the risk of cardiovascular complications as it enhances prothrombotic activity.

  3. The SERPINE1 -675 polymorphism, but not SERPINE1 -844 polymorphism, was associated with susceptibility to chronic obstructive pulmonary disease in a Chinese Han population.

  4. Increasing cell density is a negative regulator of proliferation and PAI-1 secretion both in normal and Graves' orbitopathy orbital fibroblasts; these negative regulatory effects are partially reversed in the presence of TGF-beta1 (show TGFB1 Antibodies).

  5. Fetal 4G/4G PAI-1 (OR, 0.63; 95% confidence interval, 0.43e0.91) was associated with decreased odds of stillbirth.

  6. PAI-1 4G/5G polymorphism was not significantly associated with schizophrenia.

  7. Cu(II) produces an increase in dynamics in regions important for the function and overall stability of PAI-1, while the somatomedin B (show VTN Antibodies) domain elicits virtually the opposite effect. A mutant form of PAI-1 lacking two N-terminal histidine residues at positions 2 and 3 exhibits similar increases in dynamics upon Cu(II) binding compared to that of active wild-type PAI-1.

  8. The N3 subdomain of FnBPB contains the full plasminogen (show PLG Antibodies)-binding site, and this includes, at least in part, two conserved patches of surface-located lysine residues that were recognized by kringle 4 of the host protein.

  9. The novel finding is the identification of several PAI-1 genetic variants that increase susceptibility to Osteoporotic Vertebral Compression Fractures .

  10. High levels of PAI-1 and low levels of VDR (show CYP27B1 Antibodies) expression were significantly associated with an increased risk for keloid disease in Chinese patients.

Pig (Porcine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.

Cow (Bovine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. Data show that urokinase-type plasminogen activator (uPA (show PLAU Antibodies)) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA (show PLAU Antibodies) receptor (uPAR (show PLAUR Antibodies)) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.

  2. Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation.

  3. the PI3K/Akt (show AKT1 Antibodies) pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK (show MAPK1 Antibodies) pathways

  4. high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB (show NFKB1 Antibodies) activation through the Rho/Rho-kinase (show ROCK1 Antibodies) pathway

  5. FoxO1 (show FOXO1 Antibodies) inhibits PAI-1 expression through the inhibition of TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies)-mediated signaling pathways.

SERPINE1 Antigen Profile

Antigen Summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SERPINE1

  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1) antibody
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1) antibody
  • plasminogen activator inhibitor 1 (CpipJ_CPIJ011718) antibody
  • plasminogen activator inhibitor 1 (CpipJ_CPIJ016298) antibody
  • plasminogen activator inhibitor type 1 (PAI-1) antibody
  • serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1) antibody
  • serine (or cysteine) peptidase inhibitor, clade E, member 2 (Serpine2) antibody
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) antibody
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (Serpine1) antibody
  • B230326M24Rik antibody
  • HsT1201 antibody
  • PAI antibody
  • PAI-1 antibody
  • PAI-2 antibody
  • Pai1 antibody
  • PAI1A antibody
  • Pai1aa antibody
  • PAI2 antibody
  • PI-7 antibody
  • PI7 antibody
  • Planh antibody
  • Planh1 antibody
  • PLANH2 antibody
  • PN-1 antibody
  • RATPAI1A antibody
  • SERPINE1 antibody
  • si:ch211-138a11.1 antibody
  • Spi4 antibody

Protein level used designations for SERPINE1

PAI 1 , serine (or cysteine) proteinase inhibitor, clade E, member 1 , chemokine CCL-C25s , plasminogen activator inhibitor 1 , serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 , plasminogen activator inhibitor 1-like , PAI , Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI) , endothelial plasminogen activator inhibitor , nexin, plasminogen activator inhibitor type 1 , plasminogen activator inhibitor, type I , serpin E1 , GDN , glia-derived nexin , peptidase inhibitor 7 , protease nexin 1 , protease nexin I , serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 , serine (or cysteine) proteinase inhibitor, clade E, member 2 , serine protease inhibitor 4 , serine protease-inhibitor 4 , serpin E2 , monocyte Arg-serpin , placental plasminogen activator inhibitor , plasminogen activator inhibitor 2 , plasminogen activator inhibitor, type II (arginine-serpin) , serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 , serpin B2 , urokinase inhibitor , serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 , PAI-1 , serine (or cysteine) peptidase inhibitor, clade E, member 1 , serine (or cysteine) proteinase inhibitor, member 1 , plasminogen activator inhibitor I , plasminogen activator inhibitor, type 1 , putative plasminogen activator inhibitor-1 , plasminogen activator inhibitor type 1

GENE ID SPECIES
779433 Xenopus laevis
100136840 Danio rerio
713883 Macaca mulatta
472467 Pan troglodytes
100127732 Xenopus (Silurana) tropicalis
100385528 Callithrix jacchus
100435876 Pongo abelii
100588010 Nomascus leucogenys
6045186 Culex quinquefasciatus
6050005 Culex quinquefasciatus
100381267 Ovis aries
18787 Mus musculus
20720 Mus musculus
5055 Homo sapiens
5054 Homo sapiens
24617 Rattus norvegicus
396945 Sus scrofa
281375 Bos taurus
100009588 Oryctolagus cuniculus
403476 Canis lupus familiaris
100725387 Cavia porcellus
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