anti-Chicken SERPINE1 antibody for Immunofluorescence

Recommended SERPINE1 Antibody (supplied by: Log in to see )

Antigen
serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies
  • PAI
  • PAI-1
  • PAI1
  • PLANH1
  • si:ch211-138a11.1
  • SERPINE1
  • Planh1
  • B230326M24Rik
  • PI-7
  • PI7
  • PN-1
  • Spi4
  • HsT1201
  • PAI-2
  • PAI2
  • PLANH2
  • PAI1A
  • Pai1
  • Pai1aa
  • Planh
  • RATPAI1A
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • plasminogen activator inhibitor 1
  • plasminogen activator inhibitor type 1
  • serine (or cysteine) peptidase inhibitor, clade E, member 1
  • serine (or cysteine) peptidase inhibitor, clade E, member 2
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2
  • serpine1
  • SERPINE1
  • CpipJ_CPIJ011718
  • CpipJ_CPIJ016298
  • PAI-1
  • Serpine1
  • Serpine2
  • SERPINB2
Epitope
AA 207-329
38
18
15
13
11
9
9
7
7
5
5
5
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
364
135
128
41
18
12
7
6
4
4
3
2
2
1
1
1
Host
Mouse
261
125
55
26
2
1
Clonality
Monoclonal
Conjugate
This SERPINE1 antibody is un-conjugated
44
30
17
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
331
216
119
74
44
43
36
27
27
25
20
18
10
6
6
6
5
4
4
4
4
3
1
1
1
1
1
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Catalog No. ABIN968717
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN968718 IF WB Mouse IgG1 AA 207-329 Log in to see 41-PAI 3

General

Antigen serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies
Epitope AA 207-329
(38), (18), (15), (13), (11), (9), (9), (7), (7), (5), (5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(364), (135), (128), (41), (18), (12), (7), (6), (4), (4), (3), (2), (2), (1), (1), (1)
Host Mouse
(261), (125), (55), (26), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SERPINE1 antibody is un-conjugated
(44), (30), (17), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Western Blotting (WB)
(331), (216), (119), (74), (44), (43), (36), (27), (27), (25), (20), (18), (10), (6), (6), (6), (5), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-SERPINE1 Antibody

Target Details SERPINE1 Application Details Handling ProductDetails: References for anti-SERPINE1 antibody (ABIN968717) Images
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human PAI-1 aa. 207-329
Clone 41-PAI
Isotype IgG1

Target Details SERPINE1

Product Details anti-SERPINE1 Antibody Application Details Handling ProductDetails: References for anti-SERPINE1 antibody (ABIN968717) Images back to top
Antigen
Alternative Name PAI-1 (SERPINE1 Antibody Abstract)
Background Fibrinolysis is regulated by the plasminogen activators, tissue plasminogen activator (tPA) and urokinase PA (uPA), and by the plasminogen activator-inhibitors (PAIs). Two PAIs include the serpin family members, PAI-1 and PAI-2. PAI-1 is a glycoprotein found in plasma, platelets, endothelial cells, hepatoma cells, and fibrosarcoma cells. Thrombin, endotoxin, and IL-1 induce PAI-1 synthesis in endothelial cells, which is where the major portion of plasma PAI-1 is produced. PAI-2 is a glycoprotein expressed in placenta and monocyte macrophages. The uPA/plasmin system may play a key role in cancer progression through degradation of the extracellular matrix during tumor cell migration. Paradoxically, high levels of PAI-1 are also predictive of poor prognosis of cancer patients. This finding may be a result of the role of plasmin proteolysis in the prevention of tumor vessel assembly. PAI-1 can promote tumor angiogenesis, and the mechanism may involve PAI-induced regulation of plasmin proteolysis during tumor angiogenesis. Thus, PAI-1 is a serpin protease inhibitor that is important for the regulation of plasmin proteolysis during fibrinolysis and extracellular matrix degradation.
Molecular Weight 47 kDa
Pathways p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration

Application Details

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Handling ProductDetails: References for anti-SERPINE1 antibody (ABIN968717) Images back to top
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details ProductDetails: References for anti-SERPINE1 antibody (ABIN968717) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.

ProductDetails: References for anti-SERPINE1 antibody (ABIN968717)

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details Handling Images back to top
Product cited in:

Cai, Li, Goette, Mera, Honeycutt, Feterik, Wilcox, Dudley, Harrison, Langberg: "Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke." in: Circulation, Vol. 106, Issue 22, pp. 2854-8, 2002

Bajou, Masson, Gerard, Schmitt, Albert, Praus, Lund, Frandsen, Brunner, Dano, Fusenig, Weidle, Carmeliet, Loskutoff, Collen, Carmeliet, Foidart, Noël: "The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 777-84, 2001

Ginsburg, Zeheb, Yang, Rafferty, Andreasen, Nielsen, Dano, Lebo, Gelehrter: "cDNA cloning of human plasminogen activator-inhibitor from endothelial cells." in: The Journal of clinical investigation, Vol. 78, Issue 6, pp. 1673-80, 1986

Images

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details Handling ProductDetails: References for anti-SERPINE1 antibody (ABIN968717) back to top
Supplier Images
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) (AA 207-329) antibody (ABIN968717) Western blot analysis of PAI-1 on human endothelial cell lysate. Lane 1: 1:2500, lane...