anti-Mouse (Murine) SERPINE1 antibody for Functional Studies

Recommended SERPINE1 Antibody (supplied by: Log in to see )

Antigen
serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies
  • PAI
  • PAI-1
  • PAI1
  • PLANH1
  • si:ch211-138a11.1
  • SERPINE1
  • Planh1
  • B230326M24Rik
  • PI-7
  • PI7
  • PN-1
  • Spi4
  • HsT1201
  • PAI-2
  • PAI2
  • PLANH2
  • PAI1A
  • Pai1
  • Pai1aa
  • Planh
  • RATPAI1A
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • plasminogen activator inhibitor 1
  • plasminogen activator inhibitor type 1
  • serine (or cysteine) peptidase inhibitor, clade E, member 1
  • serine (or cysteine) peptidase inhibitor, clade E, member 2
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2
  • serpine1
  • SERPINE1
  • CpipJ_CPIJ011718
  • CpipJ_CPIJ016298
  • PAI-1
  • Serpine1
  • Serpine2
  • SERPINB2
Reactivity
Mouse (Murine), Rat (Rattus)
368
135
128
41
18
13
7
6
4
4
3
2
2
2
1
1
Host
Horse
261
129
55
26
2
Clonality
Monoclonal
Conjugate
This SERPINE1 antibody is un-conjugated
44
30
17
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA)
335
216
121
74
44
43
36
27
27
26
20
17
10
6
6
6
4
4
4
4
4
3
1
1
1
1
1
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Catalog No. ABIN1108973
$ 423.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1108976 Func EIA WB Mouse IgG1 Log in to see MA-33H1F7 5
1 ABIN1108977 Func EIA IHC (fro) WB Mouse IgG1 Log in to see MA-33H1F7 3
1 ABIN1108975 Func EIA Mouse IgG1 Log in to see MA-55F4C12 3

General

Antigen serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies
Reactivity Mouse (Murine), Rat (Rattus)
(368), (135), (128), (41), (18), (13), (7), (6), (4), (4), (3), (2), (2), (2), (1), (1)
Host Horse
(261), (129), (55), (26), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SERPINE1 antibody is un-conjugated
(44), (30), (17), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Enzyme Immunoassay (EIA)
(335), (216), (121), (74), (44), (43), (36), (27), (27), (26), (20), (17), (10), (6), (6), (6), (4), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-SERPINE1 Antibody

Target Details SERPINE1 Application Details Handling References for anti-SERPINE1 antibody (ABIN1108973) Images
Specificity This antibody detects PAI-1. The antibody inhibits PAI-1 activity and simultaneously increases the binding of inactive PAI-1 to vitronectin. The effect of the antibody involves an allosteric modulation of the vitronectin binding site.
Cross-Reactivity (Details) Species reactivity (tested):Mouse, rat
Purification Protein G
Clone MA-124K1
Isotype IgG1

Target Details SERPINE1

Product Details anti-SERPINE1 Antibody Application Details Handling References for anti-SERPINE1 antibody (ABIN1108973) Images back to top
Antigen
Alternative Name SERPINE1 / PAI1 (SERPINE1 Antibody Abstract)
Background Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1
Gene ID 24617
NCBI Accession NP_036752
UniProt P20961
Pathways p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration

Application Details

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Handling References for anti-SERPINE1 antibody (ABIN1108973) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details References for anti-SERPINE1 antibody (ABIN1108973) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-SERPINE1 antibody (ABIN1108973)

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details Handling Images back to top
Background publications

Ngo, Hoylaerts, Knockaert, Brouwers, Declerck: "Identification of a target site in plasminogen activator inhibitor-1 that allows neutralization of its inhibitor properties concomitant with an allosteric up-regulation of its antiadhesive properties." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 26243-8, 2001