anti-Pig (Porcine) SERPINE1 antibody for Functional Studies

Recommended SERPINE1 Antibody (supplied by: Log in to see )

Antigen
serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies
  • PAI
  • PAI-1
  • PAI1
  • PLANH1
  • si:ch211-138a11.1
  • SERPINE1
  • Planh1
  • B230326M24Rik
  • PI-7
  • PI7
  • PN-1
  • Spi4
  • HsT1201
  • PAI-2
  • PAI2
  • PLANH2
  • PAI1A
  • Pai1
  • Pai1aa
  • Planh
  • RATPAI1A
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • plasminogen activator inhibitor 1
  • plasminogen activator inhibitor type 1
  • serine (or cysteine) peptidase inhibitor, clade E, member 1
  • serine (or cysteine) peptidase inhibitor, clade E, member 2
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2
  • serpine1
  • SERPINE1
  • CpipJ_CPIJ011718
  • CpipJ_CPIJ016298
  • PAI-1
  • Serpine1
  • Serpine2
  • SERPINB2
Reactivity
Human, Pig (Porcine)
367
136
129
41
17
13
7
6
4
4
3
2
2
2
1
1
Host
Mouse
261
128
55
26
2
1
Clonality
Monoclonal
Conjugate
This SERPINE1 antibody is un-conjugated
44
30
17
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA)
335
216
121
74
44
43
36
27
27
26
20
17
10
6
6
6
4
4
4
4
4
3
1
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Catalog No. ABIN1108974
$ 423.50
Plus shipping costs $45.00

General

Antigen serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies
Reactivity Human, Pig (Porcine)
(367), (136), (129), (41), (17), (13), (7), (6), (4), (4), (3), (2), (2), (2), (1), (1)
Host Mouse
(261), (128), (55), (26), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SERPINE1 antibody is un-conjugated
(44), (30), (17), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Enzyme Immunoassay (EIA)
(335), (216), (121), (74), (44), (43), (36), (27), (27), (26), (20), (17), (10), (6), (6), (6), (4), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1)
Pubmed 2 references available
Supplier Log in to see

Product Details anti-SERPINE1 Antibody

Target Details SERPINE1 Application Details Handling References for anti-SERPINE1 antibody (ABIN1108974) Images
Cross-Reactivity (Details) Species reactivity (tested):Human, swine
Purification Protein G
Clone MA-56A7C10
Isotype IgG1

Target Details SERPINE1

Product Details anti-SERPINE1 Antibody Application Details Handling References for anti-SERPINE1 antibody (ABIN1108974) Images back to top
Antigen
Alternative Name SERPINE1 / PAI1 (SERPINE1 Antibody Abstract)
Background Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified. The residues Glu242, Lys243 and Glu244, located in the loop connecting s3B with hG (designated loop 2) and the residues Glu350, Asp355 and Arg356, located at the distal hinge of the reactive site loop, form the major site of interaction for the monoclonal antibody MA-56A7C10. This is clearly a conformational epitope comprising residues clustered together in the three dimensional structure.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1
NCBI Accession NM_000602
UniProt P05121
Pathways p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration

Application Details

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Handling References for anti-SERPINE1 antibody (ABIN1108974) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details References for anti-SERPINE1 antibody (ABIN1108974) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-SERPINE1 antibody (ABIN1108974)

Product Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details Handling Images back to top
Background publications

Bijnens, Gils, Stassen, Komissarov, Knockaert, Brouwers, Shore, Declerck: "The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 44912-8, 2001

"Medicare program; inpatient hospital deductible for 1984--HHS. General notice." in: Federal register, Vol. 48, Issue 191, pp. 44912-3, 1983