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Mouse (Murine) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010772
Eren, Boe, Murphy, Place, Nagpal, Morales-Nebreda, Urich, Quaggin, Budinger, Mutlu, Miyata, Vaughan: PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. in Proceedings of the National Academy of Sciences of the United States of America 2014
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Mouse (Murine) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010725
Chang: Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice. in Thrombosis research 2015
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Human SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010722
Balc? Ekmekçi, Ekmekçi, Güngör, Tüten, Toprak, Korkmaz, Öncül, Çal??kan, Kucur, Donma, Madazl?, Sönmez: Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia. in Archives of gynecology and obstetrics 2015
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Rat (Rattus) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010733
Zou, Devi, Sparkenbaugh, Younis, Roth, Ganey: Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. in Toxicological sciences : an official journal of the Society of Toxicology 2009
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Human SERPINE1 ELISA Kit for Sandwich ELISA - ABIN612750
Johansson, Sørensen, Perner, Welling, Wanscher, Larsen, Ostrowski: High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. in Journal of thrombosis and haemostasis : JTH 2012
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Pig (Porcine) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010729
Duburcq, Tournoys, Viviane, Hubert, Gmyr, Pattou, Jourdain: Impact of Obesity on Endotoxin-Induced Disseminated Intravascular Coagulation. in Shock (Augusta, Ga.) 2015
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Rabbit SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010731
Florova, Azghani, Karandashova, Schaefer, Koenig, Stewart-Evans, Declerck, Idell, Komissarov: Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits. in American journal of respiratory cell and molecular biology 2015
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Rat (Rattus) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN416381
Olatunji, Usman, Seok, Kim: Activation of cardiac renin-angiotensin system and plasminogen activator inhibitor-1 gene expressions in oral contraceptive-induced cardiometabolic disorder. in Archives of physiology and biochemistry 2016
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Pig (Porcine) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010780
Thorgersen, Hellerud, Nielsen, Barratt-Due, Fure, Lindstad, Pharo, Fosse, Tønnessen, Johansen, Castellheim, Mollnes: CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
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Rat (Rattus) SERPINE1 ELISA Kit for Sandwich ELISA - ABIN2010782
Kassem, Clevenger, Szandzik, Peterson, Harding: PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts. in Prostaglandins & other lipid mediators 2014
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Notch1 (show NOTCH1 ELISA Kits) regulates the aggressive phenotypes of DTC, which could be mediated by SERPINE1 inhibition.
Genotype PAI 4G/4G is significantly more common in patients with allergic rhinitis (28.1% vs. 16.1%; P = 0.017) compared to the genotype 5G/5G. The results suggest that the carriers of at least one 4G allele are at a higher risk for developing symptoms of allergic rhinitis in asthma.
Heterozygous FV Leiden, homozygous PAI-1 4G/4G, heterozygous MTHFR C677T, homozygous MTHFR A1298C, as much as the combined thrombophilic genotypes MTHFR 677T + ACE Iota/D, MTHFR 677T/1298C + ACE D/D, ACE I/D + b-fibrinogen -455 G/A, FV HR2 + b-fibrinogen -455 G/A showed a correlation as risk factors for Recurrent pregnancy loss.
Genetic polymorphism in the promoter region of the PAI-1 gene was associated with early onset coronary artery disease.
MetS prevalence in the Ghanaian population studied was comparable to that of the industrialized West. PAI-1 may serve as a key link between MetS, as currently defined, and the endpoints with which it is associated.
MnTE-2-PyP (show PPA1 ELISA Kits) decreased p300 (show EP300 ELISA Kits) complex binding to a specific HRE motif within the PAI-1 gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 expression. Mechanistically, less p300 (show EP300 ELISA Kits) transcriptional complex binding is not due to the reduction of binding between p300 (show EP300 ELISA Kits) and HIF-1 (show HIF1A ELISA Kits)/CREB (show CREB1 ELISA Kits) transcription factors, but through inhibiting the binding of HIF-1 (show HIF1A ELISA Kits)/CREB (show CREB1 ELISA Kits) transcription factors to DNA
Study documented higher serum PAI-1 in HCV-induced hepatocellular carcinoma than viral infection-free controls, but interestingly, lower than HCV-induced liver cirrhosis patients.
transforming growth factor (TGF)-beta (show TGFB1 ELISA Kits)-induced intracellular plasminogen (show PLG ELISA Kits) activator inhibitor (PAI)-1 activation is responsible for keeping Hematopoietic stem and progenitor cells in the bone marrow niche.
PAI-1 4G/5G polymorphism plays a major role in the pathogenesis of recurrent pregnancy loss and repeated implantation failure by altering metabolic and immunological profiles.
These studies identified a copper-binding site involving histidines at positions 2 and 3 that confers a remarkable stabilization of PAI-1 beyond what is observed with vitronectin (show VTN ELISA Kits) alone. A second site, independent from the two histidines, binds metal and increases the rate of the latency conversion.
The serpin PN1 (show SCN9A ELISA Kits) is a feedback regulator of FGF signaling in germ layer and primary axis formation.
a highly dynamic endocardium in the regenerating zebrafish heart, with two key endocardial players, Serpine1 and Notch (show NOTCH1 ELISA Kits) signalling, regulating crucial regenerative processes, is reported.
SERPINe1-derived 14-mer (show MERTK ELISA Kits) peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of viral haemorrhagic septicemia virus, but also of other fish rhabdoviruses.
X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.
PAI-1 is an in vivo target of the Pla protease in the lungs, and PAI-1 is a key regulator of the pulmonary innate immune response
the role of the antifibrinolytic protein plasminogen activator inhibitor-1 (PAI-1) in alcohol enhancement of experimental endotoxin-induced acute lung injury, is reported.
PAI-1 inhibitor PAI-039 prevents smooth muscle cell migration and neointimal hyperplasia.
Tongqiaohuoxue decoction exerted an anti-thrombotic effect through the regulation of PAI-1 and fibrinolysis.
PAI-1 plays a role in maintaining gastric mucosal organization in hypergastrinemia.
Olmesartan did not significantly affect PAI1 levels in this mouse model
BRD2 (show BRD2 ELISA Kits) is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein
Neutralization of the antifibrinolytic function of PAI-1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation.
These results suggest the critical physiological role of TRL4-Fyn (show FYN ELISA Kits) interaction in the modulation of PAI-1-tPA (show PLAT ELISA Kits) axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries.
PAI-1 can promote cell migration via LRP1 (show LRP1 ELISA Kits)-dependent activation of the beta-catenin (show CTNNB1 ELISA Kits) and ERK1/2 (show MAPK1/3 ELISA Kits) MAPK (show MAPK1 ELISA Kits) pathway
In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.
Data show that urokinase-type plasminogen activator (uPA (show PLAU ELISA Kits)) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA (show PLAU ELISA Kits) receptor (uPAR (show PLAUR ELISA Kits)) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation.
the PI3K/Akt (show AKT1 ELISA Kits) pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK (show MAPK1 ELISA Kits) pathways
high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB (show NFKB1 ELISA Kits) activation through the Rho/Rho-kinase (show ROCK1 ELISA Kits) pathway
FoxO1 (show FOXO1 ELISA Kits) inhibits PAI-1 expression through the inhibition of TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits)-mediated signaling pathways.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endothelial plasminogen activator inhibitor
, plasminogen activator inhibitor 1
, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
, serpin E1
, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
, PAI 1
, serine (or cysteine) proteinase inhibitor, clade E, member 1
, putative plasminogen activator inhibitor-1
, chemokine CCL-C25s
, plasminogen activator inhibitor 1-like
, Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
, nexin, plasminogen activator inhibitor type 1
, plasminogen activator inhibitor, type I
, serine (or cysteine) peptidase inhibitor, clade E, member 1
, serine (or cysteine) proteinase inhibitor, member 1
, plasminogen activator inhibitor I
, plasminogen activator inhibitor type 1
, plasminogen activator inhibitor, type 1
, plasminogen activator inhibitor-1