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Browse our SERPINE1 Proteins (SERPINE1)

Full name:
serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Proteins (SERPINE1)
On www.antibodies-online.com are 142 serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Proteins from 18 different suppliers available. Additionally we are shipping SERPINE1 Antibodies (445) and SERPINE1 Kits (119) and many more products for this protein. A total of 729 SERPINE1 products are currently listed.
Synonyms:
B230326M24Rik, HsT1201, PAI, PAI-1, PAI-2, Pai1, PAI1A, Pai1aa, PAI2, PI-7, PI7, Planh, Planh1, PLANH2, PN-1, RATPAI1A, SERPINE1, si:ch211-138a11.1, Spi4
list all proteins Gene Name GeneID UniProt
SERPINE1 18787  
SERPINE1 5055 P05120
SERPINE1 24617 P20961

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SERPINE1 Proteins (SERPINE1) by Origin

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Top referenced SERPINE1 Proteins

  1. Human SERPINE1 Protein expressed in Human Cells - ABIN2002529 : Forsyth, Horvath, Coughlin: A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. in Genomics 2003 (PubMed)
    Show all 6 references for ABIN2002529

  2. Rat (Rattus) SERPINE1 Protein expressed in Human Cells - ABIN2009629 : Sigurdardottir, Wiman: Identification of a PAI-1 binding site in vitronectin. in Biochimica et biophysica acta 1994 (PubMed)
    Show all 5 references for ABIN2009629

  3. Rat (Rattus) SERPINE1 Protein expressed in Human Cells - ABIN2009626 : Liu, Li, Obermoeller-McCormick, Schwartz, Bu: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2009626

  4. Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN667051 : Gorlatova, Cale, Elokdah, Li, Fan, Warnock, Crandall, Lawrence: Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN667051

  5. Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544896 : Florova, Karandashova, Declerck, Idell, Komissarov: Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex. in Biochemistry 2013 (PubMed)

  6. Human SERPINE1 Protein expressed in Wheat germ - ABIN1319636 : Chung, Jorgensen, Tonry, Kashanchi, Bailey, Popov: Secreted Bacillus anthracis proteases target the host fibrinolytic system. in FEMS immunology and medical microbiology 2011 (PubMed)

More Proteins for SERPINE1 Interaction Partners

Xenopus laevis serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. The serpin PN1 (show SCN9A Proteins) is a feedback regulator of FGF signaling in germ layer and primary axis formation.

Zebrafish serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. SERPINe1-derived 14-mer (show MERTK Proteins) peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of viral haemorrhagic septicemia virus, but also of other fish rhabdoviruses.

  2. X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.

Mouse (Murine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. BRD2 (show BRD2 Proteins) is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein

  2. the involvement of PAI-1 in HIF-1 (show HIF1A Proteins)-enhanced thrombosis and that an additional factor participates in regulating Pai-1 expression in compressed skin.

  3. Neutralization of the antifibrinolytic function of PAI-1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation.

  4. These results suggest the critical physiological role of TRL4-Fyn (show FYN Proteins) interaction in the modulation of PAI-1-tPA (show PLAT Proteins) axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries.

  5. aberrant Serpine2/Pn-1 (show SERPINE2 Proteins) is required for proliferation of human and mouse medulloblastoma cells.

  6. PAI-1 can promote cell migration via LRP1 (show LRP1 Proteins)-dependent activation of the beta-catenin (show CTNNB1 Proteins) and ERK1/2 MAPK (show MAPK1 Proteins) pathway

  7. After adjusting for covariates and confounders in multiple regression analyses, only the association between leptin (show LEP Proteins) and PAI-1 remained as a factor in obesity

  8. increased PAI-1 expression promotes alveolar epithelial cell apoptosis and exacerbates lung inflammation induced by influenza A virus following passive cigarette smoke exposure.

  9. PAI-1, through its interaction with Vn, exerts multiple deleterious mechanisms to induce AKI.

  10. PN-1 (show SCN9A Proteins) strongly limits physiological angiogenesis.

Human serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. Using single fluorescence probes along the reactive center loop the study provides new insights by characterizing multiple steps in the latency transition of PAI-1.

  2. This study examines the complexes of PAI-1 with tissue-type and urokinase-type plasminogen activator (show PLAU Proteins) and vitronectin (show VTN Proteins) revealed by changes in the conformation and dynamics of the reactive center loop.

  3. Results showed an increased expression level of PAI-1 suggesting it as a potential marker of placental insufficiency and identify its close association with pathological hypoxia and angiogenesis in a subset of growth restricted pregnancies.

  4. These findings strongly support the use of uPA (show PRAP1 Proteins)/PAI-1 together with clinic-pathological parameters as an evidence-based, clinically relevant and inexpensive decision tool in the routine of a breast center.

  5. no significant correlation was demonstrated considering ACE (show ACE Proteins) and PAI-1 polymorphisms either in association with 4G/4G or D/D genotypes or a combination of them in the Iranian population in the current study.

  6. Cancer cells adhered to basal membrane secrete abundant PAI-1.

  7. the meta-analysis suggests that there are significant associations between SERPINE1 rs1799768 polymorphism and risk of sepsis and sepsis mortality.

  8. The mean level of PAI-1 was 23.02 +/- 15 (8.2-71.19) ng/mL and vitronectin (show VTN Proteins) was 83.10% +/- 23.77% (12%-126%) in the tumor group.

  9. There was no association between PAI-1 genotype and VTE recurrence in the study population as a whole, but patients with the 4G allele plus FVL (show F5 Proteins) had a higher risk of recurrence. PAI-1 polymorphism as a risk factor of recurrent VTE may be FVL (show F5 Proteins) dependent.

  10. we show that fenofibrate, a PPAR-alpha (show PPARA Proteins) agonist, increased the expression of miR (show MLXIP Proteins)-301a/miR (show MLXIP Proteins)-454 and SKA2 (show FAM33A Proteins) in human microvascular endothelial cell line (HMEC) cells; the former were responsible for reduced expression of ET-1 (show EDN1 Proteins) and PAI-1

Pig (Porcine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.

Cow (Bovine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation.

  2. the PI3K/Akt (show AKT1 Proteins) pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK (show MAPK1 Proteins) pathways

  3. high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB (show NFKB1 Proteins) activation through the Rho/Rho-kinase (show ROCK1 Proteins) pathway

  4. FoxO1 (show FOXO1 Proteins) inhibits PAI-1 expression through the inhibition of TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins)-mediated signaling pathways.

SERPINE1 Protein Profile

Protein Summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SERPINE1

  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1)
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1)
  • plasminogen activator inhibitor 1 (CpipJ_CPIJ011718)
  • plasminogen activator inhibitor 1 (CpipJ_CPIJ016298)
  • plasminogen activator inhibitor type 1 (PAI-1)
  • serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1)
  • serine (or cysteine) peptidase inhibitor, clade E, member 2 (Serpine2)
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2)
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (Serpine1)
  • B230326M24Rik protein
  • HsT1201 protein
  • PAI protein
  • PAI-1 protein
  • PAI-2 protein
  • Pai1 protein
  • PAI1A protein
  • Pai1aa protein
  • PAI2 protein
  • PI-7 protein
  • PI7 protein
  • Planh protein
  • Planh1 protein
  • PLANH2 protein
  • PN-1 protein
  • RATPAI1A protein
  • SERPINE1 protein
  • si:ch211-138a11.1 protein
  • Spi4 protein

Protein level used designations for SERPINE1

PAI 1 , serine (or cysteine) proteinase inhibitor, clade E, member 1 , chemokine CCL-C25s , plasminogen activator inhibitor 1 , serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 , plasminogen activator inhibitor 1-like , PAI , Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI) , endothelial plasminogen activator inhibitor , nexin, plasminogen activator inhibitor type 1 , plasminogen activator inhibitor, type I , serpin E1 , GDN , glia-derived nexin , peptidase inhibitor 7 , protease nexin 1 , protease nexin I , serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 , serine (or cysteine) proteinase inhibitor, clade E, member 2 , serine protease inhibitor 4 , serine protease-inhibitor 4 , serpin E2 , monocyte Arg-serpin , placental plasminogen activator inhibitor , plasminogen activator inhibitor 2 , plasminogen activator inhibitor, type II (arginine-serpin) , serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 , serpin B2 , urokinase inhibitor , serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 , PAI-1 , serine (or cysteine) peptidase inhibitor, clade E, member 1 , serine (or cysteine) proteinase inhibitor, member 1 , plasminogen activator inhibitor I , plasminogen activator inhibitor, type 1 , putative plasminogen activator inhibitor-1 , plasminogen activator inhibitor type 1

GENE ID SPECIES
779433 Xenopus laevis
100136840 Danio rerio
713883 Macaca mulatta
472467 Pan troglodytes
100127732 Xenopus (Silurana) tropicalis
100385528 Callithrix jacchus
100435876 Pongo abelii
100588010 Nomascus leucogenys
6045186 Culex quinquefasciatus
6050005 Culex quinquefasciatus
100381267 Ovis aries
18787 Mus musculus
20720 Mus musculus
5055 Homo sapiens
5054 Homo sapiens
24617 Rattus norvegicus
396945 Sus scrofa
281375 Bos taurus
100009588 Oryctolagus cuniculus
403476 Canis lupus familiaris
100725387 Cavia porcellus
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