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PAI1 Proteins

(Plasminogen Activator Inhibitor 1 (SERPINE1))
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
PAI1 Protein (AA 24-402) (His tag) PAI1 Protein (AA 24-402) (His tag) PAI1 Protein (AA 24-402) (His tag) (ABIN7275401)

SERPINE1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

PAI1 Protein (AA 24-402) (His tag) PAI1 Protein (AA 24-402) (His tag) PAI1 Protein (AA 24-402) (His tag) (ABIN7124465)

SERPINE1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

PAI1 Protein (AA 24-402) (His tag) PAI1 Protein (AA 24-402) (His tag) PAI1 Protein (AA 24-402) (His tag) (ABIN7124467)

SERPINE1 Origin: Pig Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

PAI1 Proteins by Origin

Find PAI1 Proteins for a variety of species such as anti-Human PAI1, anti-Mouse PAI1, anti-Rat PAI1. The species listed below are among those available. Click on a link to go to the corresponding products.

PAI1 Proteins by Source

Here you will find PAI1 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PAI1 Proteins by Protein Type

Here you can find PAI1 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PAI1 Proteins by Application

Find PAI1 Proteins validated for a specific application such as SDS, WB, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PAI1 Proteins by Biological Activity

Find PAI1 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular PAI1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275401
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124465
Quantity 50 μg
Datasheet Datasheet
Reactivity Pig
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124467
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320628
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1319636
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505422
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505535
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
Cat. No. ABIN7504500
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
Cat. No. ABIN1691566
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390772
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390775
Quantity 100 μg
Datasheet Datasheet
Reactivity Rabbit
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390781
Quantity 100 μg
Datasheet Datasheet
Reactivity Rhesus Monkey
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7390784
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7197367
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source
Validations
Cat. No. ABIN1048113
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our PAI1 Proteins

Reichel, Hessenauer, Pflieger, Rehberg, Kanse, Zahler, Krombach, Berghaus, Strieth: "Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116883, (2015) (PubMed).

Florova, Azghani, Karandashova, Schaefer, Koenig, Stewart-Evans, Declerck, Idell, Komissarov: "Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits." in: American journal of respiratory cell and molecular biology, Vol. 52, Issue 4, pp. 429-37, (2015) (PubMed).

Dinarvand, Hassanian, Weiler, Rezaie: "Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation." in: Blood, Vol. 125, Issue 8, pp. 1339-48, (2015) (PubMed).

Simone, Higgins, Archambeault, Higgins, Ginnan, Singer, Higgins: "A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage." in: Cellular signalling, Vol. 27, Issue 5, pp. 923-33, (2015) (PubMed).

Yang, Kuan: "Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation." in: CNS neuroscience & therapeutics, Vol. 21, Issue 4, pp. 367-73, (2015) (PubMed).

Komissarov, Florova, Azghani, Buchanan, Bradley, Schaefer, Koenig, Idell: "The time course of resolution of adhesions during fibrinolyitic therapy in tetracycline-induced pleural injury in rabbits." in: American journal of physiology. Lung cellular and molecular physiology, pp. ajplung.00136.2015, (2015) (PubMed).

Damare, Brandal, Fortenberry: "Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers." in: Nucleic acid therapeutics, Vol. 24, Issue 4, pp. 239-49, (2014) (PubMed).

Wan, Gao, Zhou, Zhang, Hao, Lian, Li, Chen, Liu: "SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence." in: Aging cell, Vol. 13, Issue 5, pp. 890-9, (2014) (PubMed).

Florova, Karandashova, Declerck, Idell, Komissarov: "Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex." in: Biochemistry, Vol. 52, Issue 27, pp. 4697-709, (2013) (PubMed).

Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).

Aliases for PAI1 Proteins

serpin family E member 1 (SERPINE1) Proteins
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog (serpine1.L) Proteins
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1) Proteins
serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1) Proteins
serpin family E member 1 (Serpine1) Proteins
PAI Proteins
PAI-1 Proteins
PAI1 Proteins
Pai1 Proteins
PAI1A Proteins
Pai1aa Proteins
Planh Proteins
PLANH1 Proteins
Planh1 Proteins
RATPAI1A Proteins
SERPINE1 Proteins
si:ch211-138a11.1 Proteins
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