You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our SERPINE1 Proteins (SERPINE1)

Full name:
serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Proteins (SERPINE1)
On www.antibodies-online.com are 157 serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Proteins from 18 different suppliers available. Additionally we are shipping SERPINE1 Antibodies (454) and SERPINE1 Kits (108) and many more products for this protein. A total of 741 SERPINE1 products are currently listed.
Synonyms:
B230326M24Rik, HsT1201, PAI, PAI-1, PAI-2, Pai1, PAI1A, Pai1aa, PAI2, PI-7, PI7, Planh, Planh1, PLANH2, PN-1, RATPAI1A, SERPINE1, si:ch211-138a11.1, Spi4
list all proteins Gene Name GeneID UniProt
SERPINE1 18787  
SERPINE1 5055 P05120
SERPINE1 24617 P20961

Show all synonyms

SERPINE1 Proteins (SERPINE1) by Origin

Select your origin of interest

Top referenced SERPINE1 Proteins

  1. Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544553 : Damare, Brandal, Fortenberry: Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers. in Nucleic acid therapeutics 2014 (PubMed)
    Show all 20 references for ABIN2544553

  2. Human SERPINE1 Protein expressed in Human Cells - ABIN2002529 : Forsyth, Horvath, Coughlin: A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. in Genomics 2003 (PubMed)
    Show all 6 references for ABIN2002529

  3. Rat (Rattus) SERPINE1 Protein expressed in Human Cells - ABIN2009629 : Sigurdardottir, Wiman: Identification of a PAI-1 binding site in vitronectin. in Biochimica et biophysica acta 1994 (PubMed)
    Show all 5 references for ABIN2009629

  4. Rat (Rattus) SERPINE1 Protein expressed in Human Cells - ABIN2009626 : Liu, Li, Obermoeller-McCormick, Schwartz, Bu: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2009626

  5. Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN667051 : Gorlatova, Cale, Elokdah, Li, Fan, Warnock, Crandall, Lawrence: Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN667051

  6. Human SERPINE1 Protein expressed in Wheat germ - ABIN1319636 : Chung, Jorgensen, Tonry, Kashanchi, Bailey, Popov: Secreted Bacillus anthracis proteases target the host fibrinolytic system. in FEMS immunology and medical microbiology 2011 (PubMed)

  7. Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544896 : Florova, Karandashova, Declerck, Idell, Komissarov: Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex. in Biochemistry 2013 (PubMed)

More Proteins for SERPINE1 Interaction Partners

Xenopus laevis serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. The serpin PN1 (show SCN9A Proteins) is a feedback regulator of FGF signaling in germ layer and primary axis formation.

Zebrafish serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. SERPINe1-derived 14-mer (show MERTK Proteins) peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of viral haemorrhagic septicemia virus, but also of other fish rhabdoviruses.

  2. X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.

Mouse (Murine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. PAI-1 plays a role in maintaining gastric mucosal organization in hypergastrinemia.

  2. Olmesartan did not significantly affect PAI1 levels in this mouse model

  3. BRD2 (show BRD2 Proteins) is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein

  4. the involvement of PAI-1 in HIF-1 (show HIF1A Proteins)-enhanced thrombosis and that an additional factor participates in regulating Pai-1 expression in compressed skin.

  5. Neutralization of the antifibrinolytic function of PAI-1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation.

  6. These results suggest the critical physiological role of TRL4-Fyn (show FYN Proteins) interaction in the modulation of PAI-1-tPA (show PLAT Proteins) axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries.

  7. aberrant Serpine2/Pn-1 (show SERPINE2 Proteins) is required for proliferation of human and mouse medulloblastoma cells.

  8. PAI-1 can promote cell migration via LRP1 (show LRP1 Proteins)-dependent activation of the beta-catenin (show CTNNB1 Proteins) and ERK1/2 MAPK (show MAPK1 Proteins) pathway

  9. After adjusting for covariates and confounders in multiple regression analyses, only the association between leptin (show LEP Proteins) and PAI-1 remained as a factor in obesity

  10. increased PAI-1 expression promotes alveolar epithelial cell apoptosis and exacerbates lung inflammation induced by influenza A virus following passive cigarette smoke exposure.

Human serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. Cu(II) produces an increase in dynamics in regions important for the function and overall stability of PAI-1, while the somatomedin B (show VTN Proteins) domain elicits virtually the opposite effect. A mutant form of PAI-1 lacking two N-terminal histidine residues at positions 2 and 3 exhibits similar increases in dynamics upon Cu(II) binding compared to that of active wild-type PAI-1.

  2. The N3 subdomain of FnBPB contains the full plasminogen (show PLG Proteins)-binding site, and this includes, at least in part, two conserved patches of surface-located lysine residues that were recognized by kringle 4 of the host protein.

  3. The novel finding is the identification of several PAI-1 genetic variants that increase susceptibility to Osteoporotic Vertebral Compression Fractures .

  4. High levels of PAI-1 and low levels of VDR (show CYP27B1 Proteins) expression were significantly associated with an increased risk for keloid disease in Chinese patients.

  5. PAI1 has a role in coronary endothelial and ventricular dysfunction after acute myocardial infarction

  6. the present study demonstrated that S1P (show MBTPS1 Proteins) induced by hypoxia increases the expression of PAI-1 in HepG2 cells via HIF-1alpha (show HIF1A Proteins) and that inhibition of S1P (show MBTPS1 Proteins) receptors may be an attractive therapeutic target and ameliorate thrombosis following hypoxia.

  7. High expression of PAI-1 is associated with colorectal carcinoma.

  8. SERPINE1 expression is upregulated in human masticatory mucosa during wound healing

  9. We concluded that overexpression of MMP-3 (show MMP3 Proteins) and uPA (show PRAP1 Proteins), altogether with diminished expression of PAI-1 from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.

  10. The carriage of mutant genotypes of PAI-I -675 5G/4G gene is a prognostic factor for rapid liver fibrosis progression in patients with Chronic hepatitis C.

Pig (Porcine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.

Cow (Bovine) serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) interaction partners

  1. Data show that urokinase-type plasminogen activator (uPA (show PLAU Proteins)) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA (show PLAU Proteins) receptor (uPAR (show PLAUR Proteins)) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.

  2. Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation.

  3. the PI3K/Akt (show AKT1 Proteins) pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK (show MAPK1 Proteins) pathways

  4. high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB (show NFKB1 Proteins) activation through the Rho/Rho-kinase (show ROCK1 Proteins) pathway

  5. FoxO1 (show FOXO1 Proteins) inhibits PAI-1 expression through the inhibition of TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins)-mediated signaling pathways.

SERPINE1 Protein Profile

Protein Summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SERPINE1

  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1)
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1)
  • plasminogen activator inhibitor 1 (CpipJ_CPIJ011718)
  • plasminogen activator inhibitor 1 (CpipJ_CPIJ016298)
  • plasminogen activator inhibitor type 1 (PAI-1)
  • serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1)
  • serine (or cysteine) peptidase inhibitor, clade E, member 2 (Serpine2)
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2)
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (Serpine1)
  • B230326M24Rik protein
  • HsT1201 protein
  • PAI protein
  • PAI-1 protein
  • PAI-2 protein
  • Pai1 protein
  • PAI1A protein
  • Pai1aa protein
  • PAI2 protein
  • PI-7 protein
  • PI7 protein
  • Planh protein
  • Planh1 protein
  • PLANH2 protein
  • PN-1 protein
  • RATPAI1A protein
  • SERPINE1 protein
  • si:ch211-138a11.1 protein
  • Spi4 protein

Protein level used designations for SERPINE1

PAI 1 , serine (or cysteine) proteinase inhibitor, clade E, member 1 , chemokine CCL-C25s , plasminogen activator inhibitor 1 , serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 , plasminogen activator inhibitor 1-like , PAI , Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI) , endothelial plasminogen activator inhibitor , nexin, plasminogen activator inhibitor type 1 , plasminogen activator inhibitor, type I , serpin E1 , GDN , glia-derived nexin , peptidase inhibitor 7 , protease nexin 1 , protease nexin I , serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 , serine (or cysteine) proteinase inhibitor, clade E, member 2 , serine protease inhibitor 4 , serine protease-inhibitor 4 , serpin E2 , monocyte Arg-serpin , placental plasminogen activator inhibitor , plasminogen activator inhibitor 2 , plasminogen activator inhibitor, type II (arginine-serpin) , serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 , serpin B2 , urokinase inhibitor , serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 , PAI-1 , serine (or cysteine) peptidase inhibitor, clade E, member 1 , serine (or cysteine) proteinase inhibitor, member 1 , plasminogen activator inhibitor I , plasminogen activator inhibitor, type 1 , putative plasminogen activator inhibitor-1 , plasminogen activator inhibitor type 1

GENE ID SPECIES
779433 Xenopus laevis
100136840 Danio rerio
713883 Macaca mulatta
472467 Pan troglodytes
100127732 Xenopus (Silurana) tropicalis
100385528 Callithrix jacchus
100435876 Pongo abelii
100588010 Nomascus leucogenys
6045186 Culex quinquefasciatus
6050005 Culex quinquefasciatus
100381267 Ovis aries
18787 Mus musculus
20720 Mus musculus
5055 Homo sapiens
5054 Homo sapiens
24617 Rattus norvegicus
396945 Sus scrofa
281375 Bos taurus
100009588 Oryctolagus cuniculus
403476 Canis lupus familiaris
100725387 Cavia porcellus
Selected quality suppliers for SERPINE1 Proteins (SERPINE1)
Did you look for something else?