Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Mouse (Murine) TANK Antibodies:
anti-Human TANK Antibodies:
anti-Rat (Rattus) TANK Antibodies:
Go to our pre-filtered search.
Human Polyclonal TANK Primary Antibody for IP, IHC - ABIN223072
Guo, Cheng: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. in The Journal of biological chemistry 2007
Show all 2 Pubmed References
TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11.
Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB (show NFKB1 Antibodies) activity and c-FLIP (show CFLAR Antibodies) expression.
TANK is critical for osteoclastogenesis by regulating NF-kappaB (show NFKB1 Antibodies), and is also important for proper bone remodeling.
role for TANK in enabling the canonical IKKs and the IKK (show CHUK Antibodies)-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity
MARCH5 (show MARCH5 Antibodies) is an authentic E3 ubiquitin ligase (show MUL1 Antibodies) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 (show MARCH5 Antibodies) modulates TLR7 (show TLR7 Antibodies) signaling via releasing the inhibitory action of TANK toward TRAF6 (show TRAF6 Antibodies).
TANK may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1 (show TBK1 Antibodies)-inducible IkappaB kinase (show IKBKE Antibodies) complex with upstream signaling molecules in multiple antiviral pathways
Therefore, Seneca Valley virus suppressed antiviral interferon (show IFNA Antibodies) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (show MAVS Antibodies), TRIF (show TRIM69 Antibodies), and TANK by its 3C protease.
Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1 (show TBK1 Antibodies)-IKKepsilon (show IKBKE Antibodies)-IRF3 (show IRF3 Antibodies) complex, resulting in reduction in IRF3 (show IRF3 Antibodies) phosphorylation and type I interferon (show IFNA Antibodies) production. (TANK = TRAF family member associated NFKB activator; TBK1 (show TBK1 Antibodies) = TANK binding kinase 1 (show TBK1 Antibodies); IKKepsilon (show IKBKE Antibodies) = inhibitor of nuclear factor kappa B kinase subunit epsilon (show IKBKE Antibodies); IRF3 (show IRF3 Antibodies) = interferon regulatory factor 3 (show IRF3 Antibodies))
Molecular basis for TANK recognition by TRAF1 (show TRAF1 Antibodies) revealed by the crystal structure of TRAF1 (show TRAF1 Antibodies)/TANK complex has been reported.
these results suggest that TANK is a novel target of some viral proteases, indicating that some positive RNA viruses have evolved to utilize their major proteases to regulate NF-kappaB (show NFKB1 Antibodies) activation.
TANK serves as an important negative regulator of NF-kappaB (show NFKB1 Antibodies) signaling cascades induced by genotoxic stress and IL-1R/Toll (show TLR4 Antibodies)-like receptor stimulation in a manner dependent on MCPIP1 (show ZC3H12A Antibodies)/USP10 (show USP10 Antibodies)-mediated TRAF6 (show TRAF6 Antibodies) deubiquitination.
two TANK gene polymorphisms (rs1921310, rs3820998) do not play a significant role in pathogenesis of chronic periodontitis or peri (show PLIN1 Antibodies)-implantitis among the Iranian population
Studies show that three proteins expressed in HEK (show EPHA3 Antibodies)-293T cells (NAP1 (show IL8 Antibodies), TANK and TBKBP1 (show TBKBP1 Antibodies)) interact with TBK1 (show TBK1 Antibodies).
SUMO modification of TANK alleviates its repression of TLR7 (show TLR7 Antibodies) signalling
Expression of TRF2 (show TERF2 Antibodies) and TANK1 (show TNKS Antibodies) increased in monoclonal gammopathy of undetermined significance and multiple myeloma.
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRAF family member-associated NFKB activator
, TRAF family member-associated NF-kappa-B activator-like
, TRAF family member-associated NF-kappa-B activator
, TRAF-interacting protein
, TRAF family member-associated Nf-kappa B activator
, TRAF interacting protein TANK