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TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11.
Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB (show NFKB1 Proteins) activity and c-FLIP (show CFLAR Proteins) expression.
TANK is critical for osteoclastogenesis by regulating NF-kappaB (show NFKB1 Proteins), and is also important for proper bone remodeling.
role for TANK in enabling the canonical IKKs and the IKK (show CHUK Proteins)-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity
MARCH5 (show MARCH5 Proteins) is an authentic E3 ubiquitin ligase (show MUL1 Proteins) and catalyzes K63-linked polyubiquitination of TANK. MARCH5 (show MARCH5 Proteins) modulates TLR7 (show TLR7 Proteins) signaling via releasing the inhibitory action of TANK toward TRAF6 (show TRAF6 Proteins).
TANK may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1 (show TBK1 Proteins)-inducible IkappaB kinase (show IKBKE Proteins) complex with upstream signaling molecules in multiple antiviral pathways
Therefore, Seneca Valley virus suppressed antiviral interferon (show IFNA Proteins) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (show MAVS Proteins), TRIF (show TRIM69 Proteins), and TANK by its 3C protease.
Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1 (show TBK1 Proteins)-IKKepsilon (show IKBKE Proteins)-IRF3 (show IRF3 Proteins) complex, resulting in reduction in IRF3 (show IRF3 Proteins) phosphorylation and type I interferon (show IFNA Proteins) production. (TANK = TRAF family member associated NFKB activator; TBK1 (show TBK1 Proteins) = TANK binding kinase 1 (show TBK1 Proteins); IKKepsilon (show IKBKE Proteins) = inhibitor of nuclear factor kappa B kinase subunit epsilon (show IKBKE Proteins); IRF3 (show IRF3 Proteins) = interferon regulatory factor 3 (show IRF3 Proteins))
Molecular basis for TANK recognition by TRAF1 (show TRAF1 Proteins) revealed by the crystal structure of TRAF1 (show TRAF1 Proteins)/TANK complex has been reported.
these results suggest that TANK is a novel target of some viral proteases, indicating that some positive RNA viruses have evolved to utilize their major proteases to regulate NF-kappaB (show NFKB1 Proteins) activation.
TANK serves as an important negative regulator of NF-kappaB (show NFKB1 Proteins) signaling cascades induced by genotoxic stress and IL-1R/Toll (show TLR4 Proteins)-like receptor stimulation in a manner dependent on MCPIP1 (show ZC3H12A Proteins)/USP10 (show USP10 Proteins)-mediated TRAF6 (show TRAF6 Proteins) deubiquitination.
two TANK gene polymorphisms (rs1921310, rs3820998) do not play a significant role in pathogenesis of chronic periodontitis or peri (show PLIN1 Proteins)-implantitis among the Iranian population
Studies show that three proteins expressed in HEK (show EPHA3 Proteins)-293T cells (NAP1 (show IL8 Proteins), TANK and TBKBP1 (show TBKBP1 Proteins)) interact with TBK1 (show TBK1 Proteins).
SUMO modification of TANK alleviates its repression of TLR7 (show TLR7 Proteins) signalling
Expression of TRF2 (show TERF2 Proteins) and TANK1 (show TNKS Proteins) increased in monoclonal gammopathy of undetermined significance and multiple myeloma.
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRAF family member-associated NFKB activator
, TRAF family member-associated NF-kappa-B activator-like
, TRAF family member-associated NF-kappa-B activator
, TRAF-interacting protein
, TRAF family member-associated Nf-kappa B activator
, TRAF interacting protein TANK