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anti-Human TNFRSF10B antibody for Functional Studies

Recommended TNFRSF10B Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies
  • cd262
  • CD262
  • dr5
  • DR5
  • killer
  • KILLER
  • KILLER/DR5
  • Ly98
  • MK
  • TNFRSF10B
  • TRAIL-R2
  • TRAILR2
  • trailr2
  • TRICK2
  • trick2
  • TRICK2A
  • trick2a
  • trick2b
  • TRICK2B
  • trickb
  • TRICKB
  • xDR-M1
  • xDR-M2
  • ztnfr9
  • ZTNFR9
Reactivity
Human
348
69
19
1
1
1
Host
Mouse
191
180
10
8
7
2
Clonality
Monoclonal
Conjugate
This TNFRSF10B antibody is un-conjugated
26
24
18
7
6
6
5
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
1
1
Application
Functional Studies (Func), Immunoprecipitation (IP)
195
187
70
44
41
34
23
22
16
14
13
5
3
3
3
1
1
Supplier
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Catalog No. ABIN1106163
$ 308.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008771965 ABIN1106164 Func Mouse IgG1 Log in to see B-K29 2
0.0008771965 ABIN1169245 Func ICC FACS IP Mouse IgG1 Log in to see HS201 6
0.0008771965 ABIN1169242 Func ICC FACS IP Biotin Mouse IgG1 Log in to see HS201
0.0008771965 ABIN2629393 Func ICC FACS IP Biotin Mouse IgG1 Log in to see HS201
0.0008771965 ABIN1169243 Func ICC FACS IP Mouse IgG1 Log in to see HS201
0.0008771965 ABIN1722625 Func FACS ELISA Mouse IgG1 Log in to see B-K29
0.0008771965 ABIN1722626 Func FACS IP ELISA Mouse IgG2b Log in to see B-D37
0.0008771965 ABIN2139406 Func Mouse IgG1 kappa Log in to see DJR2-4
0.0008771965 ABIN2139408 Func Mouse IgG1 kappa Log in to see DJR2-2

Top referenced anti-TNFRSF10B antibody for Functional Studies

Similar anti-TNFRSF10B Antibodies

Application / Reactivity Human
ELISA 60 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies
Flow Cytometry (FACS) 178 Antibodies
Functional Studies (Func) 10 Antibodies
Immunochromatography (IC) 14 Antibodies
Immunocytochemistry (ICC) 40 Antibodies
Immunofluorescence (IF) 17 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 12 Antibodies
Immunohistochemistry (IHC) 41 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antibodies
Immunoprecipitation (IP) 20 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Neutralization (Neut) 3 Antibodies
Western Blotting (WB) 174 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies
Reactivity Human
(348), (69), (19), (1), (1), (1)
Host Mouse
(191), (180), (10), (8), (7), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF10B antibody is un-conjugated
(26), (24), (18), (7), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Application Functional Studies (Func), Immunoprecipitation (IP)
(195), (187), (70), (44), (41), (34), (23), (22), (16), (14), (13), (5), (3), (3), (3), (1), (1)
Pubmed 1 reference available
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Product Details anti-TNFRSF10B Antibody

Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B Antibody (ABIN1106163) Images
Specificity Recognizes the soluble antigen. Recognizes the 42-46 kDa protein.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ion Exchange Chromatography.
Sterility 0.22 μm filtered
Immunogen Recombinant Human TRAIL R2/Fc chimera. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Clone B-D37
Isotype IgG2b

Target Details TNFRSF10B

Product Details anti-TNFRSF10B Antibody Application Details Handling References for anti-TNFRSF10B Antibody (ABIN1106163) Images back to top
Antigen
Alternative Name CD262 / TRAILR2 (TNFRSF10B Antibody Abstract)
Background TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Synonyms: DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9
Gene ID 8795
NCBI Accession NP_003833
UniProt O14763
Research Area Signaling, Apoptosis/Necrosis
Pathways p53 Signaling, Apoptosis

Application Details

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling References for anti-TNFRSF10B Antibody (ABIN1106163) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details References for anti-TNFRSF10B Antibody (ABIN1106163) Images back to top
Concentration 1.0 mg/mL
Buffer Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
Preservative Without preservative
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

References for anti-TNFRSF10B Antibody (ABIN1106163)

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling Images back to top
Background publications

Mérino, Lalaoui, Morizot, Schneider, Solary, Micheau: "Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7046-55, 2006