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|Application / Reactivity||Mouse (Murine)|
|ELISA (Capture)||1 Antibodies|
|Flow Cytometry (FACS)||13 Antibodies|
|Functional Studies (Func)||1 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||8 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Western Blotting (WB)||30 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF10B antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS), Immunoprecipitation (IP)
|7 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF10B AntibodyTarget Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B Antibody (ABIN2663239) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details TNFRSF10BProduct Details anti-TNFRSF10B Antibody Application Details Handling References for anti-TNFRSF10B Antibody (ABIN2663239) Images back to top
|Alternative Name||CD262 (TNFRSF10B Antibody Abstract)|
|Background||CD262 is a 55 kD protein also known as DR5, TRAIL-R2, Apo-2, TRICK2, and KILLER. DR5 is member 10B of the TNF receptor superfamily (TNFRSF10B), widely expressed in normal tissues and some tumor cell lines. The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP. TRAIL binding to DR5 activates NF- κB and induces apoptosis. DR5 is induced by wild-type p53.|
|Pathways||p53 Signaling, Apoptosis|
Application DetailsProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling References for anti-TNFRSF10B Antibody (ABIN2663239) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details References for anti-TNFRSF10B Antibody (ABIN2663239) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFRSF10B Antibody (ABIN2663239)Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling Images back to top
Young, Cooley, Chauhan et al.: "Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts." in: Bone, Vol. 48, Issue 4, pp. 857-63, 2011 (PubMed).
Grisendi, Bussolari, Cafarelli et al.: "Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy." in: Cancer research, Vol. 70, Issue 9, pp. 3718-29, 2010 (PubMed).
Iannello, Samarani, Debbeche et al.: "Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells." in: Journal of virology, Vol. 83, Issue 12, pp. 5999-6010, 2009 (PubMed).
Sato, Nakaoka, Yamashita et al.: "TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 7, pp. 4025-33, 2005 (PubMed).
Takeda, Yamaguchi, Akiba et al.: "Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy." in: The Journal of experimental medicine, Vol. 199, Issue 4, pp. 437-48, 2004 (PubMed).
Hayakawa, Screpanti, Yagita et al.: "NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 1, pp. 123-9, 2003 (PubMed).
Wu, Burns, Zhan et al.: "Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor." in: Cancer research, Vol. 59, Issue 12, pp. 2770-5, 1999 (PubMed).
ImagesProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B Antibody (ABIN2663239) back to top