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|Application / Reactivity||Human||Mouse (Murine)|
|Cytometry by Time of Flight (CyTOF)||2 Antibodies|
|Western Blotting (WB)||173 Antibodies||37 Antibodies|
|Neutralization (Neut)||3 Antibodies||1 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies||1 Antibodies|
|Immunoprecipitation (IP)||20 Antibodies||3 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||29 Antibodies||8 Antibodies|
|Immunohistochemistry (IHC)||42 Antibodies||8 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies||3 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||12 Antibodies|
|Immunofluorescence (IF)||16 Antibodies||3 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF10B antibody is un-conjugated Alternatives|
Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-TNFRSF10B AntibodyTarget Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B Antibody (ABIN222914) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412716|
|Specificity||The antibody detects 60 kDa DR5 in samples of human and mouse origins.|
|Immunogen||Synthetic peptide corresponding to residues surrounding amino acid 372 of mouse DR5 precursor|
Target Details TNFRSF10BProduct Details anti-TNFRSF10B Antibody Application Details Handling References for anti-TNFRSF10B Antibody (ABIN222914) Images back to top
|Alternative Name||DR5 (TNFRSF10B Antibody Abstract)|
DR5 is the DD containing receptor for TRAIL, Apo2, TRAIL-R2, TRICK2, or KILLER. DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. Like DR3 and TNFR1, DR5 mediate apoptosis by FADD dependent pathway. Over-expression of DR5 induces apoptosis and activates NFkB.
Synonyms: TNFRSF10B, TRICKB,TRANCE-R, ZTNFR9, CD262, TRICK2A, Apo2, TRAIL-R2, TRICK2, KILLER
|Research Area||Cancer, Growth Factors, Apoptosis/Necrosis, Death Receptors, Signaling|
|Pathways||p53 Signaling, Apoptosis|
Application DetailsProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling References for anti-TNFRSF10B Antibody (ABIN222914) Images back to top
Western blot analysis (0.5-4 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details References for anti-TNFRSF10B Antibody (ABIN222914) Images back to top
|Buffer||100 μg (0.2 mg/mL) immunoaffinity purified rabbit anti-DR5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-TNFRSF10B Antibody (ABIN222914)Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling Images back to top
|Product cited in:||
Erster, Mihara, Kim, Petrenko, Moll: "In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6728-41, 2004
ImagesProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B Antibody (ABIN222914) back to top