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|Antigen||Tripartite Motif Containing 29 (TRIM29) Antibodies|
|Epitope||Internal Region Alternatives|
|Reactivity||Chimpanzee, Cow (Bovine), Horse (Equine), Human, Macaque, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRIM29 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-TRIM29 AntibodyTarget Details TRIM29 Application Details Handling Images
|Specificity||This antibody reacts to TRIM29 / ATDC.|
Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human, Horse, Bovine, Chimpanzee, Macaque.
|Characteristics||Concentration: 0.67 mg/mL (by UV absorbance at 280 nm)|
|Immunogen||Peptide corresponding to an internal portion of human ATDC protein around lysine 116|
Target Details TRIM29Product Details anti-TRIM29 Antibody Application Details Handling Images back to top
|Alternative Name||TRIM29 / ATDC (TRIM29 Antibody Abstract)|
|Background||Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.Synonyms: Ataxia-telangiectasia group D-associated protein, Tripartite motif-containing protein 29|
|Pathways||p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus|
Application DetailsProduct Details anti-TRIM29 Antibody Target Details TRIM29 Handling Images back to top
ELISA: 1/100000. Westerm Blot: 1/500 - 1/3000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRIM29 Antibody Target Details TRIM29 Application Details Images back to top
|Buffer||0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|