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|Antigen||Xeroderma Pigmentosum, Complementation Group C (XPC) Antibodies|
|Conjugate||This XPC antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
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Product Details anti-XPC AntibodyTarget Details XPC Application Details Handling Images
|Specificity||Reacts with Human 105 kDa XPC protein.|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Purification||Affinity Chromatography on Protein A|
|Immunogen||Synthetic peptide derived from C-terminal domain of Human XPC protein|
Target Details XPCProduct Details anti-XPC Antibody Application Details Handling Images back to top
|Alternative Name||XPC / XPCC (XPC Antibody Abstract)|
|Background||Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair. XPC may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XPC), also known as xeroderma pigmentosum III (XP3). XPC is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.Synonyms: DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125|
|Pathways||p53 Signaling, DNA Damage Repair|
Application DetailsProduct Details anti-XPC Antibody Target Details XPC Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-XPC Antibody Target Details XPC Application Details Images back to top
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer|