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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies|
|Immunofluorescence (IF)||5 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||11 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies|
|Western Blotting (WB)||52 Antibodies|
|Antigen||Xeroderma Pigmentosum, Complementation Group C (XPC) Antibodies|
|Epitope||AA 141-251 Alternatives|
|Conjugate||This XPC antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-XPC AntibodyTarget Details XPC Application Details Handling References for anti-XPC Antibody (ABIN396711) Images
|Specificity||XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details XPCProduct Details anti-XPC Antibody Application Details Handling References for anti-XPC Antibody (ABIN396711) Images back to top
|Alternative Name||XPC (XPC Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||105981 DA|
|Research Area||Cell Structure|
|Pathways||p53 Signaling, DNA Damage Repair|
Application DetailsProduct Details anti-XPC Antibody Target Details XPC Handling References for anti-XPC Antibody (ABIN396711) Images back to top
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
Background: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
|Restrictions||For Research Use only|
HandlingProduct Details anti-XPC Antibody Target Details XPC Application Details References for anti-XPC Antibody (ABIN396711) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-XPC Antibody (ABIN396711)Product Details anti-XPC Antibody Target Details XPC Application Details Handling Images back to top
Palli, Polidoro, DErrico et al.: "Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer." in: Mutagenesis, Vol. 25, Issue 6, pp. 569-75, 2010 (PubMed).
Long, Ma, Zhou et al.: "Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1301-9, 2010 (PubMed).
Figl, Scherer, Nagore et al.: "Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma." in: Mutation research, Vol. 702, Issue 1, pp. 8-16, 2010 (PubMed).
Guillem, Cervantes, Martínez et al.: "XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia." in: American journal of hematology, Vol. 85, Issue 7, pp. 482-6, 2010 (PubMed).
Zhu, Xu, Hong et al.: "XPC gene intron 11 C/A polymorphism is a predictive biomarker for the sensitivity to NP chemotherapy in patients with non-small cell lung cancer." in: Anti-cancer drugs, Vol. 21, Issue 7, pp. 669-73, 2010 (PubMed).
ImagesProduct Details anti-XPC Antibody Target Details XPC Application Details Handling References for anti-XPC Antibody (ABIN396711) back to top