anti-Human XPC antibody for ELISA

Recommended XPC Antibody (supplied by: Log in to see )

Antigen
Xeroderma Pigmentosum, Complementation Group C (XPC) Antibodies
  • RAD4
  • XP3
  • XPCC
  • xeroderma pigmentosum, complementation group C
  • XPC
  • LOC100346279
  • Xpc
Epitope
AA 141-251
18
15
13
7
5
3
3
2
1
1
1
Reactivity
Human
98
34
20
1
Host
Mouse
75
28
Clonality
Monoclonal
Conjugate
This XPC antibody is un-conjugated
8
8
7
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
77
32
31
28
24
21
13
5
2
2
1
1
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Catalog No. ABIN396711
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.499393 ABIN563389 ELISA WB Mouse IgG2a kappa AA 141-250, partial Log in to see 6D11
1 ABIN1583828 ELISA WB Rabbit C-Term Log in to see Polyclonal
1 ABIN1829132 ELISA WB Mouse IgG2a, kappa AA 141-250 Log in to see 6D11
1 ABIN1948985 ELISA WB FITC Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN1948984 ELISA WB Alkaline Phosphatase (AP) Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN1948986 ELISA WB Biotin Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN1948987 ELISA WB APC Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN1948989 ELISA WB HRP Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN1948988 ELISA WB PE Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN2568927 ELISA IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal
1 ABIN2568930 ELISA WB Rabbit IgG AA 154-183 Log in to see Polyclonal
1 ABIN2568928 ELISA IHC (p) WB FITC Rabbit IgG Log in to see Polyclonal
1 ABIN2568929 ELISA IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal
1 ABIN563388 ELISA WB Mouse AA 141-250, partial Log in to see Polyclonal
1 ABIN2390763 ELISA WB PE Rabbit IgG N-Term, AA 154-183 Log in to see Polyclonal
1 ABIN2390769 ELISA WB Rabbit IgG N-Term, AA 154-183 Log in to see Polyclonal
1 ABIN2390768 ELISA WB HRP Rabbit IgG N-Term, AA 154-183 Log in to see Polyclonal
1 ABIN2390765 ELISA WB APC Rabbit IgG N-Term, AA 154-183 Log in to see Polyclonal
1 ABIN2390767 ELISA WB FITC Rabbit IgG N-Term, AA 154-183 Log in to see Polyclonal
1 ABIN2390766 ELISA WB Biotin Rabbit IgG N-Term, AA 154-183 Log in to see Polyclonal

General

Antigen Xeroderma Pigmentosum, Complementation Group C (XPC) Antibodies
Epitope AA 141-251
(18), (15), (13), (7), (5), (3), (3), (2), (1), (1), (1)
Reactivity Human
(98), (34), (20), (1)
Host Mouse
(75), (28)
Clonality (Clone)
Monoclonal   ( )
Conjugate This XPC antibody is un-conjugated
(8), (8), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Western Blotting (WB)
(77), (32), (31), (28), (24), (21), (13), (5), (2), (2), (1), (1)
Pubmed 5 references available
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Product Details anti-XPC Antibody

Target Details XPC Application Details Handling ProductDetails: References for anti-XPC antibody (ABIN396711) Images
Specificity XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6D11
Isotype IgG2a kappa

Target Details XPC

Product Details anti-XPC Antibody Application Details Handling ProductDetails: References for anti-XPC antibody (ABIN396711) Images back to top
Antigen
Alternative Name XPC (XPC Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 105981 DA
Gene ID 12406
NCBI Accession NP_004619
Research Area Cell Structure
Pathways p53 Signaling, DNA Damage Repair

Application Details

Product Details anti-XPC Antibody Target Details XPC Handling ProductDetails: References for anti-XPC antibody (ABIN396711) Images back to top
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only

Handling

Product Details anti-XPC Antibody Target Details XPC Application Details ProductDetails: References for anti-XPC antibody (ABIN396711) Images back to top
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

ProductDetails: References for anti-XPC antibody (ABIN396711)

Product Details anti-XPC Antibody Target Details XPC Application Details Handling Images back to top
Background publications

Palli, Polidoro, DErrico, Saieva, Guarrera, Calcagnile, Sera, Allione, Gemma, Zanna, Filomena, Testai, Caini, Moretti, Gomez-Miguel, Nesi, Luzzi, Ottini, Masala, Matullo, Dogliotti: "Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer." in: Mutagenesis, Vol. 25, Issue 6, pp. 569-75, 2010

Long, Ma, Zhou, Ma, Fu: "Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1301-9, 2010

Figl, Scherer, Nagore, Bermejo, Botella-Estrada, Gast, Thirumaran, Planelles, Hemminki, Schadendorf, Kumar: "Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma." in: Mutation research, Vol. 702, Issue 1, pp. 8-16, 2010

Guillem, Cervantes, Martínez, Alvarez-Larrán, Collado, Camós, Sureda, Maffioli, Marugán, Hernández-Boluda: "XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia." in: American journal of hematology, Vol. 85, Issue 7, pp. 482-6, 2010

Zhu, Xu, Hong, Yue, Zhang, Ye, Yuan: "XPC gene intron 11 C/A polymorphism is a predictive biomarker for the sensitivity to NP chemotherapy in patients with non-small cell lung cancer." in: Anti-cancer drugs, Vol. 21, Issue 7, pp. 669-73, 2010

Images

Product Details anti-XPC Antibody Target Details XPC Application Details Handling ProductDetails: References for anti-XPC antibody (ABIN396711) back to top
Supplier Images
ELISA image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 141-251) antibody (ABIN396711) Detection limit for recombinant GST tagged XPC is approximately 0.03 ng/mL as a captu...