anti-Mouse (Murine) XPC antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended XPC Antibody (supplied by: Log in to see )

Antigen
Xeroderma Pigmentosum, Complementation Group C (XPC) Antibodies
  • RAD4
  • XP3
  • XPCC
  • xeroderma pigmentosum, complementation group C
  • XPC
  • LOC100346279
  • Xpc
Epitope
AA 880-920
18
14
13
7
5
3
3
2
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
98
33
19
1
Host
Rabbit
74
29
Clonality
Polyclonal
Conjugate
This XPC antibody is un-conjugated
8
8
7
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
77
32
31
28
24
21
12
5
2
2
1
1
Options
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Catalog No. ABIN719171
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN719177 IF (p) Cy7 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN719174 IF (p) Cy3 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN719175 IF (p) Cy5 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN719176 IF (p) Cy5.5 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN719178 IF (p) FITC Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN920204 IF (p) Alexa Fluor 350 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN920205 IF (p) Alexa Fluor 488 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN920206 IF (p) Alexa Fluor 555 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN920207 IF (p) Alexa Fluor 647 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN2807586 IF (p) Alexa Fluor 594 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN5012552 IF (p) Alexa Fluor 750 Rabbit IgG AA 880-920 Log in to see Polyclonal
1 ABIN5012551 IF (p) Alexa Fluor 680 Rabbit IgG AA 880-920 Log in to see Polyclonal

General

Antigen Xeroderma Pigmentosum, Complementation Group C (XPC) Antibodies
Epitope AA 880-920
(18), (14), (13), (7), (5), (3), (3), (2), (2), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(98), (33), (19), (1)
Host Rabbit
(74), (29)
Clonality
Polyclonal
Conjugate This XPC antibody is un-conjugated
(8), (8), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(77), (32), (31), (28), (24), (21), (12), (5), (2), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-XPC Antibody

Target Details XPC Application Details Handling References for anti-XPC antibody (ABIN719171) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Xeroderma pigmentosum group C
Isotype IgG

Target Details XPC

Product Details anti-XPC Antibody Application Details Handling References for anti-XPC antibody (ABIN719171) Images back to top
Antigen
Alternative Name Xpc (XPC Antibody Abstract)
Background

Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.

Subcellular location: Cytoplasm, Nucleus

Synonyms: XP3, RAD4, XPCC, p125, DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, XPC

Gene ID 7508
UniProt Q01831
Pathways p53 Signaling, DNA Damage Repair

Application Details

Product Details anti-XPC Antibody Target Details XPC Handling References for anti-XPC antibody (ABIN719171) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-XPC Antibody Target Details XPC Application Details References for anti-XPC antibody (ABIN719171) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-XPC antibody (ABIN719171)

Product Details anti-XPC Antibody Target Details XPC Application Details Handling Images back to top
Product cited in:

Biswas, Mitchell, Johnson: "E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis." in: Cancer research, Vol. 74, Issue 12, pp. 3369-77, 2014

Images

Product Details anti-XPC Antibody Target Details XPC Application Details Handling References for anti-XPC antibody (ABIN719171) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-XPC Polyc...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boil...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Paraformaldehyde-fixed, paraffin embedded human colon carcinoma tissue, Antigen retri...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Paraformaldehyde-fixed, paraffin embedded human kidney tissue, Antigen retrieval by b...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Paraformaldehyde-fixed, paraffin embedded human cervical carcinoma tissue, Antigen re...
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Paraformaldehyde-fixed, paraffin embedded human colon carcinoma tissue, Antigen retri...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 880-920) antibody (ABIN719171) Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boil...