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These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
PAX2 (show PAX2 Proteins), PAX8 (show PAX8 Proteins), CDX2 immunostains was preformed to the TMA slides.
In stomach adenocarcinomas, CDH17 positively stained 64.0% (112 of 175) of tissues, compared to CK20 (show KRT20 Proteins) and CDX2, where staining was observed in only 24.6% (43 of 175) and 46.9% (82 of 175), respectively.
CDX2 expression correlates with gastric and intestinal differentiation in Barrett's esophagus towards adenocarcinoma.
CDX2 inhibited pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR (show MLXIP Proteins)-615-5p. Our findings suggested a potential molecular target for pancreatic adenocarcinoma therapy.
Suggest that NKX6.3 (show NKX6-3 Proteins) might function as a master regulator of gastric differentiation by affecting SOX2 (show SOX2 Proteins) and CDX2 expression and the NKX6.3 (show NKX6-3 Proteins) inactivation may result in intestinal metaplasia in gastric epithelial cells.
Immunohistochemical panel of CDX2, p120ctn, c-Myc, and Jagged1 proteins would be to distinguish between low/high grade dysplasia in histologically challenging cases of Barrett's esophagus.
CDX2 single-nucleotide polymorphism is associated with cancer risk.
CK7 (show KRT7 Proteins), TTF-1 (show NKX2-1 Proteins) and napsin A (show NAPSA Proteins) are predominantly expressed in primary lung adenocarcinoma patients, with CDX-2 being inconsistently expressed.
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (show HOXB7 Proteins) and Cdx2 in colon cancer cells.
Changes in CDX1 (show CDX1 Proteins)/CDX2 mRNA expression in gastric mucosa following H. pylori eradication showed only insignificant results
showed novel molecular regulation of CDX2 on Oct4 (show POU5F1 Proteins), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (show POU5F1 Proteins) in embryo of mammals other than mouse
CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs (show NFS1 Proteins) may be activated or repressed.
cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass.
findings illuminated a role for NOD1 (show NOD1 Proteins) signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells
Overexpression of CDX2 inhibits the growth of the gastric cancer cells in vivo and in vitro.
Intestinal stem cells transform into gastric stem cells on loss of transcription factor Cdx2.
GATA4 (show GATA4 Proteins) and HNF4A (show HNF4A Proteins) control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2
pSMAD (show SMAD1 Proteins)/CDX2 interaction is essential for the switch toward an intestinal phenotype in Barrett's esophagus.
Cdx2 is important for the correct specification of trophoectoderm from the morula stage.
These findings underscore previously unrecognized roles for Cdx (show CDX1 Proteins) members in intestinal tumorigenesis
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2