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These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
Data show that a two-marker panel of p40 (show IL9 Proteins) (DeltaNp63) and CDX2 is highly sensitive and specific.
our findings demonstrated that MDR1 expression is regulated by CDX2 and is related to drug resistance in ovarian mucinous adenocarcinoma.
The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 (show LAMC2 Proteins) in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (show TNF Proteins) is present.
Cytapheresis might induce CDX2 expression without affecting the cell proliferation, thus resulting in mucosal healing with goblet cell restoration.
SOX2 (show SOX2 Proteins) expression induces a cellular stem cell state in human colorectal cancer (CRC (show CALR Proteins)) with a decreased expression of CDX2. Furthermore, a down-regulated expression of CDX2 results in a poor patient prognosis in CRC (show CALR Proteins).
A small subset (5%) of hepatocellular carcinomas are CDX2 positive.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha (show HNF4A Proteins) were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha (show HNF4A Proteins) in human biopsy samples.
Colon cancer cells expressing CDX2 are less deformable, a feature that has been shown to correlate with poor metastatic potential.
Results show that CDX2 and Fbw7 expression is inversely correlated during colon cell differentiation and that CDX2 expression is regulated by Fbw7 in a GSK3b-dependent manner.
Aberrant DNA methylation (show HELLS Proteins) of SOX2 (show SOX2 Proteins) and CDX2 genes contributes to the development of IM. Notably, SOX2 (show SOX2 Proteins) may play a role in establishing and maintaining the methylation status of the CDX2 gene in gastric tissues and cells.
Data show that SLC7A7 (show Slc7a7 Proteins) is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 (show Slc7a7 Proteins) promoter.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4 (show POU5F1 Proteins), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (show POU5F1 Proteins) in embryo of mammals other than mouse
including Wnt (show WNT2 Proteins) and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx (show CDX1 Proteins)/Hox (show MSH2 Proteins) and T Brachyury (show TBX1 Proteins) transcriptional networks controls differential axial growth during vertebrate trunk elongation
Cdx (show CDX1 Proteins) members interact with the SWI (show SMARCA1 Proteins)-SNF (show SNRPA Proteins) complex and make direct contact with Brg1 (show SMARCA4 Proteins), a catalytic member of SWI (show SMARCA1 Proteins)-SNF (show SNRPA Proteins). Both Cdx2 and Brg1 (show SMARCA4 Proteins) co-occupy a number of Cdx (show CDX1 Proteins) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 (show SMARCA4 Proteins) occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox (show MSH2 Proteins) gene.
Cdx1 (show CDX1 Proteins)-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (show ADCY10 Proteins) and a block in hematopoietic differentiation from yolk sac (show ADCY10 Proteins)-derived cells in culture.
this study shows that Aloe vera (show IGF2BP3 Proteins) gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (show HOXB7 Proteins) and Cdx2 in colon cancer cells.
CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs (show NFS1 Proteins) may be activated or repressed.
cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass.
findings illuminated a role for NOD1 (show NOD1 Proteins) signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2