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Human Polyclonal EXO84 Primary Antibody for EIA, WB - ABIN952141
Issaq, Lim, Counter: Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. in Molecular cancer research : MCR 2010
Show all 5 references for ABIN952141
We identified interactions between RalA (show rala Antibodies) and its effectors sec5 (show EXOC2 Antibodies) and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells.
shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells.
evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral (show rala Antibodies) GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 (show EXOC2 Antibodies) and Exo84
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
exocyst complex component 8
, exocyst complex 84-kDa subunit
, Exocyst complex component 8
, exocyst complex 84 kDa subunit
, putative protein, with a coiled coil domain, of eukaryotic origin (77.8 kD) (1P228)