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Human Polyclonal EXOC6 Primary Antibody for ICC, IF - ABIN4309740
Suriben, Kaihara, Paolino, Reichelt, Kummerfeld, Modrusan, Dugger, Newton, Sagolla, Webster, Liu, Hebrok, Dixit: β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1. in Cell 2015
The Sec15 protein, a known Rab11 (show RAB11A Antibodies) effector and a component of the exocyst, is necessary for Notch (show NOTCH1 Antibodies) activation and the resolution of distinct sibling cell fates in the sensory organ precursors lineage.
In fly photoreceptors Sec15 colocalizes with Rab11 (show RAB11A Antibodies) and that loss of Sec15 affects rhabdomere morphology.
NDR2 (show STK38L Antibodies)-mediated Rabin8 (show RAB3IP Antibodies) phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 (show RAB3IP Antibodies) from PS to Sec15.
coordinated disruption of the Rab11 (show RAB11A Antibodies)/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection
Sec15 has a role as an effector for the Rab11 GTPase (show RAB11A Antibodies) in mammalian cells
The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery.
These results suggest that the association of Rab10 (show RAB10 Antibodies)-GTP (show AK3 Antibodies) with Exoc6/6b is a molecular link between insulin (show INS Antibodies) signaling and the exocytic machinery in GLUT4 (show SLC2A4 Antibodies) translocation.
Mutation in Sec15l1 causes anemia in hemoglobin deficit mice.
Iron metabolism mutant hbd mice have an exon deletion in Sec15l1.
These data indicate that rapid transferrin (show Tf Antibodies) recycling is defective after pSec15l1 has mutated.
Exoc3l (show EXOC3L1 Antibodies) is involved in regulated exocytosis of insulin (show INS Antibodies) granules; expressed in insulin (show INS Antibodies)-secreting cells as well as in various tissues including pancreatic islets and brain.
The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
, exocyst complex component 6
, SEC15-like 1
, SEC15-like 2
, SEC15-like protein 1
, SEC15-like protein 3
, exocyst complex component Sec15A
, SEC15 homolog
, Exocyst complex component Sec15A