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The Sec15 protein, a known Rab11 (show RAB11A ELISA Kits) effector and a component of the exocyst, is necessary for Notch (show NOTCH1 ELISA Kits) activation and the resolution of distinct sibling cell fates in the sensory organ precursors lineage.
In fly photoreceptors Sec15 colocalizes with Rab11 (show RAB11A ELISA Kits) and that loss of Sec15 affects rhabdomere morphology.
NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 from PS to Sec15.
coordinated disruption of the Rab11 (show RAB11A ELISA Kits)/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection
Sec15 has a role as an effector for the Rab11 GTPase (show RAB11A ELISA Kits) in mammalian cells
The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery.
These results suggest that the association of Rab10 (show RAB10 ELISA Kits)-GTP (show AK3 ELISA Kits) with Exoc6/6b is a molecular link between insulin (show INS ELISA Kits) signaling and the exocytic machinery in GLUT4 (show SLC2A4 ELISA Kits) translocation.
Mutation in Sec15l1 causes anemia in hemoglobin deficit mice.
Iron metabolism mutant hbd mice have an exon deletion in Sec15l1.
These data indicate that rapid transferrin (show Tf ELISA Kits) recycling is defective after pSec15l1 has mutated.
Exoc3l (show EXOC3L1 ELISA Kits) is involved in regulated exocytosis of insulin (show INS ELISA Kits) granules; expressed in insulin (show INS ELISA Kits)-secreting cells as well as in various tissues including pancreatic islets and brain.
The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
, exocyst complex component 6
, SEC15-like 1
, SEC15-like 2
, SEC15-like protein 1
, SEC15-like protein 3
, exocyst complex component Sec15A
, SEC15 homolog
, Exocyst complex component Sec15A