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Data reinforces the importance of activin-betaC in reproductive biology and suggests that activin-betaC is a tumor modulator with gonadal specificity.
Data support the conclusion that activin inhibits adrenal tumor growth promoted by luteinizing hormone by inducing adrenal x-zone regression.
results indicate that the beta(C) and beta(E) subunits of activin form homo- and heterodimers, and that the functions of the two subunits are quite different
Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist.
Serum inhibin levels correlate with clinical characteristics and mortality in epithelial ovarian cancer patients.
The inhibin-betaC subunit is down-regulated, while inhibin-betaE is up-regulated by interferon (show IFNA Proteins)-beta1a in Ishikawa carcinoma cell line.
Single Nucleotide Polymorphisms in INHBC gene is associated with brain metastasis in non-small-cell lung cancer
Activin-beta(C) is a regulator of activin-A (show INHBA Proteins). Activin-beta(C) is able to abolish cachexia and modulate reproductive tumour development in inhibin alpha-subunit (show INHA Proteins) knockout mice (alpha-KO) mice.
inhibin-betaC in normal and pathological placental tissue was demonstrated, although no differences in staining intensity could be observed. Functional role of novel inhibin-betaC subunit in normal and pathological human placenta is still quite unclear.
Data show that inhibin A levels were significantly lower in the PCOS group compared to the control group, and inhibin B levels were comparable in the two groups.
the novel inhibin/activin-betaC subunit is expressed in human endometrioid adenocarcinomas and in the human endometrial carcinoma cell line HEC (show NDC80 Proteins)-1a
Expression of the inhibin betaC and betaE subunits was demonstrated at the protein level and at the transcriptional level in normal human endometrial tissue and in the Ishikawa human endometrial carcinoma cell line.
Expression of inhibin beta C was detected in the human chorionic carcinoma cell lines JEG and BeWoand also in human placenta.
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.
inhibin, beta C
, Activin beta-C chain
, activin beta-C chain
, activin/inhibin beta C
, inhibin beta C chain