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Human Polyclonal MBOAT4 Primary Antibody for EIA, IHC (p) - ABIN953340
Takahashi, Ida, Sato, Nakashima, Nakamura, Tsuji, Kojima: Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid. in Journal of biochemistry 2009
Show all 3 references for ABIN953340
Human Polyclonal MBOAT4 Primary Antibody for IHC (p), WB - ABIN656250
Gómez, Lago, Gómez-Reino, Dieguez, Gualillo: Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes. in Arthritis and rheumatism 2009
Show all 2 references for ABIN656250
GOAT prefers n-hexanoyl-CoA over n-octanoyl-CoA as the acyl donor, although in the stomach the n-octanoyl form is the predominant form of acyl-modified ghrelin (show GHRL Antibodies).
The GOAT active site was characterized by defining substrate-enzyme interactions used to bind and recognize ghrelin (show GHRL Antibodies).
Studies suggest that dysregulation in the components of the ghrelin (show GHRL Antibodies) system including ghrelin (show GHRL Antibodies), ghrelin receptor (show GHSR Antibodies) (GHSR1a) and ghrelin (show GHRL Antibodies)-O-acyl-transferase can lead to or influence the development and/or progression of highly concerning pathologies.
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.
Data indicate that ghrelin O-acyltransferase (GOAT) mRNA and protein are expressed in the normal prostate and prostate cancer tissue samples.
Genetic variation of the ghrelin (show GHRL Antibodies) activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. (Review)
Identification of GOAT expression in various tissues support the concept that in addition to the important endocrine effect of acylated ghrelin (show GHRL Antibodies), the paracrine effects of locally synthetised and acylated ghrelin (show GHRL Antibodies) may be important.
Modulation of GOAT or ghrelin (show GHRL Antibodies) signaling may be a clinically relevant strategy to treat metabolic diseases such as type II diabetes.
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin (show GHRL Antibodies).
The identification and characterization of human GOAT, the ghrelin (show GHRL Antibodies) O-acyl transferase, is reported.
circadian rhythmicity of ghrelin (show GHRL Antibodies) signaling requires Bmal1 (show ARNTL Antibodies) and is driven by a food-responsive clock in the gastric ghrelin (show GHRL Antibodies)-secreting cell that not only regulates ghrelin (show GHRL Antibodies), but also GOAT activity.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone (show GH1 Antibodies) release and patterning
Altered lipid and salt taste responsivity in ghrelin (show GHRL Antibodies) and GOAT null mice.
The absence of GOAT does not alter glucose intolerance suggesting that desacyl/acyl ghrelin (show GHRL Antibodies) is not a major denominator for glucose homeostasis.
GOAT induced ghrelin (show GHRL Antibodies) acylation regulates hedonic feeding.
The endogenous GOAT-ghrelin-growth hormone secretagogue receptor (show GHSR Antibodies) system is not essential for the maintenance of euglycemia during prolonged calorie restriction.
While there is considerable overlap in expression pattern between ghrelin (show GHRL Antibodies) and ghrelin O-acyltransferase (GOAT), the latter exhibits some unique tissue expression that could suggest that additional peptides may be acylated and await discovery.(Review)
This is the first report that the GOAT/ghrelin (show GHRL Antibodies) system regulates bile acid metabolism, and these findings suggest a novel function of GOAT in the regulation of intestinal bile acid reabsorption..
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone (show GH1 Antibodies)-mediated survival of calorie-restricted mice
The present study demonstrates that stomach GOAT mRNA levels correlate with circulating acylated-ghrelin (show GHRL Antibodies) levels in fasted and diet-induced obese mice.
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
O-acyltransferase (membrane bound) domain containing 4
, O-acyltransferase domain-containing protein 4
, ghrelin O-acyltransferase
, membrane-bound O-acyltransferase domain-containing protein 4