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Mouse (Murine) MBOAT4 ELISA Kit for Sandwich ELISA - ABIN844312
Nahata, Saegusa, Sadakane, Yamada, Nakagawa, Okubo, Ohnishi, Hattori, Sakamoto, Takeda: Administration of exogenous acylated ghrelin or rikkunshito, an endogenous ghrelin enhancer, improves the decrease in postprandial gastric motility in an acute restraint stress mouse model. in Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2014
Plasma GOAT levels exhibit high specificity/sensitivity to predict prostate carcinoma-presence compared with other PCa (show FLVCR1 ELISA Kits)-biomarkers, especially in non-diabetic individuals.
The role of ghrelin O-acyltransferase cysteine residue in the ghrelin (show GHRL ELISA Kits) acylation
GOAT prefers n-hexanoyl-CoA over n-octanoyl-CoA as the acyl donor, although in the stomach the n-octanoyl form is the predominant form of acyl-modified ghrelin (show GHRL ELISA Kits).
The GOAT active site was characterized by defining substrate-enzyme interactions used to bind and recognize ghrelin (show GHRL ELISA Kits).
Studies suggest that dysregulation in the components of the ghrelin (show GHRL ELISA Kits) system including ghrelin (show GHRL ELISA Kits), ghrelin receptor (show GHSR ELISA Kits) (GHSR1a) and ghrelin (show GHRL ELISA Kits)-O-acyl-transferase can lead to or influence the development and/or progression of highly concerning pathologies.
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.
Data indicate that ghrelin O-acyltransferase (GOAT) mRNA and protein are expressed in the normal prostate and prostate cancer tissue samples.
Genetic variation of the ghrelin (show GHRL ELISA Kits) activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. (Review)
Identification of GOAT expression in various tissues support the concept that in addition to the important endocrine effect of acylated ghrelin (show GHRL ELISA Kits), the paracrine effects of locally synthetised and acylated ghrelin (show GHRL ELISA Kits) may be important.
Modulation of GOAT or ghrelin (show GHRL ELISA Kits) signaling may be a clinically relevant strategy to treat metabolic diseases such as type II diabetes.
Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1 (show LEPROTL1 ELISA Kits). Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in wild-type mice. This was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin (show GHRL ELISA Kits) levels. But it was absent in the GHSR1a knockout mouse hippocampus, implying that the expression of GHSR1a may be a prerequisite for the production of GOAT.
Both ghrelin (show GHRL ELISA Kits) and GOAT are localized primarily in the red pulp of the spleen. Importantly, in the thymus, ghrelin (show GHRL ELISA Kits) was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Both regulates obesity-induced inflammation.
anxiogenic actions of GOAT deletion not related to high plasma des (show DES ELISA Kits)-acyl ghrelin (show GHRL ELISA Kits)
circadian rhythmicity of ghrelin (show GHRL ELISA Kits) signaling requires Bmal1 (show ARNTL ELISA Kits) and is driven by a food-responsive clock in the gastric ghrelin (show GHRL ELISA Kits)-secreting cell that not only regulates ghrelin (show GHRL ELISA Kits), but also GOAT activity.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
Altered lipid and salt taste responsivity in ghrelin (show GHRL ELISA Kits) and GOAT null mice.
The absence of GOAT does not alter glucose intolerance suggesting that desacyl/acyl ghrelin (show GHRL ELISA Kits) is not a major denominator for glucose homeostasis.
GOAT induced ghrelin (show GHRL ELISA Kits) acylation regulates hedonic feeding.
The endogenous GOAT-ghrelin-growth hormone secretagogue receptor (show GHSR ELISA Kits) system is not essential for the maintenance of euglycemia during prolonged calorie restriction.
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
O-acyltransferase (membrane bound) domain containing 4
, O-acyltransferase domain-containing protein 4
, ghrelin O-acyltransferase
, membrane-bound O-acyltransferase domain-containing protein 4