Browse our anti-PCSK1 (PCSK1) Antibodies

Full name:
anti-Proprotein Convertase Subtilisin/kexin Type 1 Antibodies (PCSK1)
On are 32 Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Antibodies from 15 different suppliers available. Additionally we are shipping PCSK1 Proteins (9) and PCSK1 Kits (8) and many more products for this protein. A total of 53 PCSK1 products are currently listed.
BDP, BMIQ12, Nec-1, Nec1, PC1, PC1/3, PC3, Phpp-1, SPC3
list all antibodies Gene Name GeneID UniProt
PCSK1 5122 P29120
PCSK1 25204 P28840
PCSK1 18548 P63239

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Top referenced anti-PCSK1 Antibodies

  1. Human Monoclonal PCSK1 Primary Antibody for IF, WB - ABIN395943 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for 395943

  2. Human Polyclonal PCSK1 Primary Antibody for ELISA - ABIN1995767 : Jackson, Creemers, Farooqi, Raffin-Sanson, Varro, Dockray, Holst, Brubaker, Corvol, Polonsky, Ostrega, Becker, Bertagna, Hutton, White, Dattani, Hussain, Middleton, Nicole, Milla, Lindley, ORahilly: Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. in The Journal of clinical investigation 2003 (PubMed)
    Show all 3 references for 1995767

  3. Mouse (Murine) Polyclonal PCSK1 Primary Antibody for WB - ABIN267188 : Evans, Fernando, Ragolia: Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells. in Molecular and cellular endocrinology 2012 (PubMed)
    Show all 2 references for 267188

  4. Cow (Bovine) Polyclonal PCSK1 Primary Antibody for IHC, WB - ABIN2778153 : Rehfeld, Bundgaard, Hannibal, Zhu, Norrbom, Steiner, Friis-Hansen: The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6. in Endocrinology 2008 (PubMed)

More Antibodies against PCSK1 Interaction Partners

Zebrafish Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Pcsk1 has been sequenced and characterized.

Human Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. PCSK1 mutations are associated with Obesity.

  2. PCSK1 expression is significantly upregulated in human masticatory mucosa during wound healing

  3. these common variants in PCSK1 and POMC (show POMC Antibodies) were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.

  4. we demonstrate evidence that common gene variation in PCSK1 contributes to BMI variation and susceptibility to common obesity in the largest known meta-analysis published to date in genetic epidemiology.

  5. Data show that prohormone convertase 1/3 (PC1/3) endoplasmic reticulum-retained mutants induce endoplasmic reticulum stress.


  7. We showed for the first time that a nonsense mutation in PCSK1 was likely to cause dominantly inherited human obesity, due to the inhibiting properties of the propeptide fragment encoded by the null allele

  8. Epistases between single nucleotide polymorphisms within proprotein convertase subtilisin/kexin type 1(PCSK1) and dopamine beta-hydroxylase(DBH (show DBH Antibodies)) genes are significantly associated with susceptibility or resistance to premature ovarian failure

  9. FTO (show FTO Antibodies)-rs9939609, TMEM18 (show TMM18 Antibodies)-rs6548238 and PCSK1-rs6234 polymorphisms are significantly associated with body mass index in a southern Chinese population.

  10. Common genetic variants in PCSK1 are associated with coronary artery disease in Chinese patients with type 2 diabetes.

Cow (Bovine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Prohormone convertase PC1 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.

  2. a model of the membrane topology of the prohomone convertase PC3, where it is anchored to lipid rafts in secretory granule membranes via the transmembrane domain

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha (show TNF Antibodies), IL6 (show IL6 Antibodies), IL1alpha (show IL1A Antibodies) and CXCL2 (show CXCL2 Antibodies).

  2. PC1 and PC2 (show CBX4 Antibodies) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 Antibodies) protein

  3. Binding of MAGP2 (show MFAP5 Antibodies) to microfibrils is regulated by proprotein convertase cleavage.

  4. Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme.

  5. proSAAS (show PCSK1N Antibodies) as a novel down-regulated target of Pax6 (show PAX6 Antibodies)

  6. Loss of PC1 in mice showed a dramatic decrease in the biosynthesis of all proTRH-derived peptides analyzed including TRH (show TRH Antibodies) and its immediate precursor TRH (show TRH Antibodies)-Gly.

  7. PC1/3 also has an important role in the regulation of the innate immune system, most likely through the regulation of cytokine secretion in macrophages.

  8. Reports demonstrate that mouse proprotein convertase 1/3 (mPC1 (show BRP44L Antibodies)/3) has a lag (show STMN1 Antibodies) phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis.

  9. Intraislet production of GLP-1 (show GCG Antibodies) by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of ss-cell regeneration.

  10. Data suggest that PC1/3 and many convertase-specific properties are attributable less to convertase-specific catalytic cleft residues than to convertase-specific domain interactions.

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Study identified 14 polymorphisms that were organized in nine haplotypes, clearly distributed in two clades of putative European and Asian origin and showed that the porcine PCSK1 gene is associated with fat deposition.

PCSK1 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PCSK1

  • proprotein convertase subtilisin/kexin type 1 (pcsk1) antibody
  • prohormone convertase 1 (PC1B) antibody
  • prohormone convertase 1 (LOC100534403) antibody
  • prohormone convertase 1 (LOC100534404) antibody
  • proprotein convertase subtilisin/kexin type 1 (PCSK1) antibody
  • proprotein convertase subtilisin/kexin type 1 (Pcsk1) antibody
  • BDP antibody
  • BMIQ12 antibody
  • Nec-1 antibody
  • Nec1 antibody
  • PC1 antibody
  • PC1/3 antibody
  • PC3 antibody
  • Phpp-1 antibody
  • SPC3 antibody

Protein level used designations for PCSK1

neuroendocrine convertase 1 , prohormone convertase 1 , NEC 1 , prohormone convertase 3 , Protein convertase subtilisin / kexin type I , Protein convertase subtilisin / kexin, type I , proprotein convertase 1 , furin homolog , prohormone convertase 1/3 , propeptide-processing protease , prohormone convertase

100005716 Danio rerio
100533213 Aplysia californica
100534403 Oreochromis niloticus
100534404 Oreochromis niloticus
5122 Homo sapiens
25204 Rattus norvegicus
281967 Bos taurus
18548 Mus musculus
479149 Canis lupus familiaris
397103 Sus scrofa
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