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anti-Human RAB27A Antibodies:
anti-Mouse (Murine) RAB27A Antibodies:
anti-Rat (Rattus) RAB27A Antibodies:
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Human Monoclonal RAB27A Primary Antibody for IHC (p), RNAi - ABIN562560
Kimura, Kaneko, Yamada, Ishihara, Senda, Iwamatsu, Niki: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines. in Journal of cell science 2008
Show all 8 Pubmed References
Human Polyclonal RAB27A Primary Antibody for WB - ABIN1881720
Ohbayashi, Mamishi, Ishibashi, Maruta, Pourakbari, Tamizifar, Mohammadpour, Fukuda, Parvaneh: Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2. in Pigment cell & melanoma research 2010
Show all 5 Pubmed References
Human Monoclonal RAB27A Primary Antibody for WB - ABIN967619
Hong: Cytotoxic T lymphocyte exocytosis: bring on the SNAREs! in Trends in cell biology 2005
Show all 3 Pubmed References
Rat (Rattus) Polyclonal RAB27A Primary Antibody for IP, WB - ABIN1742354
Lovis, Roggli, Laybutt, Gattesco, Yang, Widmann, Abderrahmani, Regazzi: Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. in Diabetes 2008
Show all 2 Pubmed References
Rat (Rattus) Polyclonal RAB27A Primary Antibody for IP, WB - ABIN1742353
de Wit, Walter, Milosevic, Gulyás-Kovács, Riedel, Sørensen, Verhage: Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. in Cell 2009
RAB27A, RAB27B (show RAB27B Antibodies) and VPS36 (show VPS36 Antibodies) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (show RAB27B Antibodies) and VPS36 (show VPS36 Antibodies), with RAB27A and RAB27B (show RAB27B Antibodies) being dependent on VPS36 (show VPS36 Antibodies).
identified small molecule inhibitors of Rab27a-JFC1 (show SYTL1 Antibodies) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (show HRB Antibodies) GTPases and their effectors.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
decreased expression of Rab27A and Rab27B (show RAB27B Antibodies), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).
Data suggest that microRNA miR (show MLXIP Antibodies)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (show CALR Antibodies)) by targeting RAS-related GTP-binding protein (show RAB10 Antibodies) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (show CALR Antibodies).
Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.
miR (show MLXIP Antibodies)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle
Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.
Our data indicate that RAB27A expression is an independent prognostic marker for pancreatic ductal adenocarcinoma
Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (show CSF2 Antibodies)-dependent neutrophil priming is involved.
These results suggest that the dual effector, Noc2 (show RPH3AL Antibodies), regulates the transition from Rab2a (show RAB2A Antibodies)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Loss of Rab3D (show RAB3D Antibodies) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (show RAB3D Antibodies) activity, may contribute to the enhanced release of cathepsin S (show CTSS Antibodies) in tears of patients with Sjogren's syndrome.
The Rab27A regulates CG exocytosis following MII-stage oocyte activation.
Given that GTP (show AK3 Antibodies)- and GDP-bound Rab27a regulate exocytosis.
This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (show CACNA1D Antibodies) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (show VEGFA Antibodies) secretion by the retinal pigment epithelium.
results show that Rab27A is present in mouse pancreatic acinar cells and mainly regulates secretion through the minor-regulated pathway
Rab27A deficiency shows the increased surface level of c-fms (show CSF1R Antibodies), and the delayed downregulation of RANK in ashen cells, resulting in enhanced signaling of M-CSF (show CSF1R Antibodies) and RANKL (show TNFSF11 Antibodies).
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RAB27A, member RAS oncogene family
, Ras-related protein Rab-27A
, rab27a, member ras oncogene family
, ras-related protein Rab-27A
, GTP-binding protein Ram
, member RAS oncogene family, RAB27A
, low Mr GTP-binding protein
, ram p25
, RAS oncogene family member