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These results demonstrated that miR (show MLXIP ELISA Kits)-145 has an inhibitory role in TNBC malignancy by targeting MMP11 (show MMP11 ELISA Kits) and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.
RAB27A, RAB27B (show RAB27B ELISA Kits) and VPS36 (show VPS36 ELISA Kits) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (show RAB27B ELISA Kits) and VPS36 (show VPS36 ELISA Kits), with RAB27A and RAB27B (show RAB27B ELISA Kits) being dependent on VPS36 (show VPS36 ELISA Kits).
identified small molecule inhibitors of Rab27a-JFC1 binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (show HRB ELISA Kits) GTPases and their effectors.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
decreased expression of Rab27A and Rab27B (show RAB27B ELISA Kits), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).
Data suggest that microRNA miR (show MLXIP ELISA Kits)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (show CALR ELISA Kits)) by targeting RAS-related GTP-binding protein (show RAB10 ELISA Kits) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (show CALR ELISA Kits).
Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.
miR (show MLXIP ELISA Kits)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle
Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.
miR (show MLXIP ELISA Kits)-124 has an important role in osteoclastogenesis via targeting Rab27a.
this study shows that Rab27a and Rab27b (show RAB27B ELISA Kits) double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (show CSF2 ELISA Kits)-dependent neutrophil priming is involved.
These results suggest that the dual effector, Noc2 (show RPH3AL ELISA Kits), regulates the transition from Rab2a (show RAB2A ELISA Kits)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Loss of Rab3D (show RAB3D ELISA Kits) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (show RAB3D ELISA Kits) activity, may contribute to the enhanced release of cathepsin S (show CTSS ELISA Kits) in tears of patients with Sjogren's syndrome.
The Rab27A regulates CG exocytosis following MII-stage oocyte activation.
Given that GTP (show AK3 ELISA Kits)- and GDP-bound Rab27a regulate exocytosis.
This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (show CACNA1D ELISA Kits) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (show VEGFA ELISA Kits) secretion by the retinal pigment epithelium.
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RAB27A, member RAS oncogene family
, Ras-related protein Rab-27A
, rab27a, member ras oncogene family
, ras-related protein Rab-27A
, GTP-binding protein Ram
, member RAS oncogene family, RAB27A
, low Mr GTP-binding protein
, ram p25
, RAS oncogene family member