Activating Transcription Factor 7 Interacting Protein (ATF7IP) (Middle Region) Peptide
ATF7IP
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all MCAF1 (ATF7IP) products
- MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))
- Protein Region
- Middle Region
- Origin
- Human, Mouse
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MSTPEGEKSE KDGKAEEEER VPAEEQPPVR NEFSRRKRSK SEDMDSVESK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Atf7ip Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))
- Synonyms
- ATF7IP Peptide, AM Peptide, MCAF Peptide, MCAF1 Peptide, p621 Peptide, 2610204M12Rik Peptide, Mcaf1 Peptide, fa12g02 Peptide, wu:fa12g02 Peptide, zgc:152981 Peptide, activating transcription factor 7 interacting protein Peptide, Atf7ip Peptide, ATF7IP Peptide, atf7ip Peptide
- Background
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Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.
Alias Symbols: 2610204M12Rik, AM, Mcaf1
Protein Size: 1306 - Molecular Weight
- 138 kDa
- Gene ID
- 54343
- NCBI Accession
- NM_019426, NP_062299
- UniProt
- Q7TT18
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