Axin 1 (AXIN1) (N-Term) Peptide
AXIN1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all Axin (AXIN1) products
- Axin (AXIN1) (Axin 1 (AXIN1))
- Protein Region
- N-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- Synthetic peptide located within the following region: < a href='http://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_SEQUENCE=on&NCBI_GI=on&ALIGNMENTS =50&I_THRESH=0.005&QUERY=
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Axin1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Axin (AXIN1) (Axin 1 (AXIN1))
- Synonyms
- AXIN1 Peptide, axin Peptide, fused Peptide, xAxin Peptide, LOC100226467 Peptide, AXIN Peptide, PPP1R49 Peptide, AI316800 Peptide, Axin Peptide, Fu Peptide, Kb Peptide, Ki Peptide, kinky Peptide, knobbly Peptide, AXIN1-RGS Peptide, wu:fi22e03 Peptide, wu:fj14c08 Peptide, wu:fk11b03 Peptide, zgc:109872 Peptide, axin 1 Peptide, axin 1 S homeolog Peptide, axin 1 L homeolog Peptide, AXIN1 Peptide, axin1.S Peptide, axin1.L Peptide, Axin1 Peptide, axin1 Peptide
- Background
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Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects, down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.
Alias Symbols: AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
Protein Size: 993 - Molecular Weight
- 110 kDa
- Gene ID
- 12005
- NCBI Accession
- XM_914907, XP_920000
- UniProt
- O70239
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