Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (N-Term) Peptide
CDKN1A
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all p21 (CDKN1A) products
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Sequence
- KACRRLFGPV DSEQLSRDCD ALMAGCIQEA RERWNFDFVT ETPLEGDFAW
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CDKN1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- Synonyms
- CCND1 Peptide, CDKN1A Peptide, CAP20 Peptide, CDKN1 Peptide, CIP1 Peptide, MDA-6 Peptide, P21 Peptide, SDI1 Peptide, WAF1 Peptide, p21CIP1 Peptide, CDKI Peptide, Cdkn1 Peptide, Waf1 Peptide, mda6 Peptide, p21Cip1 Peptide, p21WAF Peptide, Cip1 Peptide, UV96 Peptide, p21 Peptide, cip1 Peptide, p16Xic2 Peptide, sdi1 Peptide, waf1 Peptide, cap20 Peptide, cdkn1 Peptide, mda-6 Peptide, p21cip1 Peptide, si:ch1073-48m5.2 Peptide, KRAS2 Peptide, p21ras Peptide, cyclin D1 Peptide, cyclin dependent kinase inhibitor 1A Peptide, cyclin-dependent kinase inhibitor 1A (P21) Peptide, cyclin-dependent kinase inhibitor 1A Peptide, cyclin-dependent kinase inhibitor 1A L homeolog Peptide, cyclin-dependent kinase inhibitor 1 Peptide, KRAS proto-oncogene, GTPase Peptide, CCND1 Peptide, CDKN1A Peptide, Cdkn1a Peptide, cdkn1a.L Peptide, cki1 Peptide, cdkn1a Peptide, KRAS Peptide
- Background
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This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
Alias Symbols: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Protein Size: 164 - Molecular Weight
- 18 kDa
- Gene ID
- 1026
- NCBI Accession
- NM_078467, NP_510867
- UniProt
- Q6FI05
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