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Heparin-Binding EGF-Like Growth Factor (HBEGF) (N-Term) Peptide

HBEGF Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN2184563
  • Target See all HBEGF products
    HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    FLAAVLSALV TGESLERLRR GLAAGTSNPD PPTVSTDQLL PLGGGRDRKV
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-HBEGF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
    Synonyms
    hbegf Peptide, zgc:165443 Peptide, HBEGF Peptide, zgc:175091 Peptide, DTR Peptide, DTS Peptide, DTSF Peptide, HEGFL Peptide, Dtr Peptide, GFHB Peptide, Hb-egf Peptide, Hegfl Peptide, AW047313 Peptide, Dts Peptide, HB-EGF Peptide, heparin-binding EGF-like growth factor b Peptide, heparin binding EGF like growth factor Peptide, Heparin-binding EGF-like growth factor Peptide, heparin-binding EGF-like growth factor a Peptide, heparin-binding EGF-like growth factor Peptide, hbegfb Peptide, HBEGF Peptide, hbegf Peptide, hbegfa Peptide, Hbegf Peptide
    Background
    HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.

    Alias Symbols: DTR, DTS, DTSF, HEGFL

    Protein Size: 208
    Molecular Weight
    22 kDa
    Gene ID
    1839
    NCBI Accession
    NM_001945, NP_001936
    UniProt
    Q99075
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