Angiopoietin 2 (ANGPT2) (Middle Region) Peptide
ANGPT2
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all Angiopoietin 2 (ANGPT2) products
- Angiopoietin 2 (ANGPT2)
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NQTTRLELQL LQHSISTNKL EKQILDQTSE INKLQNKNSF LEQKVLDMEG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Angpt2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Angiopoietin 2 (ANGPT2)
- Synonyms
- AGPT2 Peptide, ANG2 Peptide, Agpt2 Peptide, Ang-2 Peptide, Ang2 Peptide, ang2 Peptide, angpt2 Peptide, ANGIOPOIETIN-2 Peptide, ANG-2 Peptide, ANGPT2 Peptide, Angrp Peptide, Rnase5b Peptide, ANG3 Peptide, C11orf2 Peptide, C11orf3 Peptide, FFR Peptide, angiopoietin 2 Peptide, angiopoietin 2b Peptide, angiogenin, ribonuclease A family, member 2 Peptide, VPS51, GARP complex subunit Peptide, ANGPT2 Peptide, Angpt2 Peptide, angpt2b Peptide, Ang2 Peptide, VPS51 Peptide
- Background
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Angpt2 binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Alias Symbols: Agpt2, Ang-2, Ang2
Protein Size: 496 - Molecular Weight
- 56 kDa
- Gene ID
- 11601
- NCBI Accession
- NM_007426, NP_031452
- UniProt
- O35608
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