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Details for Product No. ABIN493064

Interleukin 17A (IL17A) Peptide

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Protein Name
Synonyms IL17, CTLA8, IL-17, IL-17A, Ctla-8, Ctla8, Il17, ChIL-17, IL-17F, IL17A, CTLA-8
Application
Control Peptide (CP)
Pubmed 4 references available
Catalog no. ABIN493064
Quantity 0.25 mg
Price
242.00 $   Plus shipping costs $45.00
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Alternative Name Interleukin-17A (IL17A)
Background The primary function of the body defense mechanism/immune system is to protect the organism from invading pathogens. In this regard a very effective and dynamic cellular network has evolved that comprise of innate and adaptive immunity. Most components of innate immunity are present before the onset of infection and constitute cellular and molecular components that recognize classes of molecules peculiar to pathogens. In contrast, adaptive immunity responds to the challenge with a high degree of specificity as well as the remarkable property of memory. Although adaptive immune responses are the most effective to clear invading pathogens (1, 2), innate immune responses should be precedent of activation of adaptive immune cells (2). In other words, adaptive immune responses can not arise without help of innate immune responses. Antigen presenting cells (APCs) are key initiators of immune responses. During infection various cytochines are released and via activation of various TLR receptor family, they synthesized various interleukins. IL17 gene was mapped at a single site on mouse chromosome 1A and human chromosome 2q31 (2). Pro inflammatory cytokine, IL-17 (IL-17A or CTLA-8) plays a central role in inflammation and autoimmunity. The iIL17, like other cytokines is produce by activation of T cell receptor through CD3 cross linking (1). IL-17 is a crucial effector cytokine, whose production is specifically triggered by IL-23, and it has been shown to be an essential inflammatory mediator in other autoimmune diseases and inflammatory conditions. In human the co- stimulation of T cells thru CD28 several costimulatory molecules (ICOS, 4-1BB, CD40L) mildly enhance the IL17 expression where as IL23 profoundly enhance the CD3 induced IL17 expression. The IL-17 expression is also sensitive to cyclosporin-A and MAPK inhibitors, suggesting the involvement of the calcineurin/NFAT and MAPK signaling pathways. The predicted 155-amino acids sequence contains an N-terminal signal peptide and exhibits 72% amino acid identity with HVS13, an open reading frame from a T-lymphotropic Herpesvirus saimiri, and 63% with murine CTLA8 (3). Based on hydropathy plot has 2 transmembrane domains (TMD) at N and C-terminal end of the protein. The anti-IL17 antibodies were made against an epitope that lies near the extracytoplasmic domain on IL17 protien.
Alternate names: CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17
Gene ID 3605
NCBI Accession NP_002181
UniProt Q16552
Research Area Cytokines, Receptors, Inflammation, Immunology, Virology, Cancer
Comment

Antigenic blocking peptide for ABIN493065

Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Yao, Painter, Fanslow et al.: "Human IL-17: a novel cytokine derived from T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 12, pp. 5483-6, 1996 (PubMed).

Rouvier, Luciani, Mattéi et al.: "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 12, pp. 5445-56, 1993 (PubMed).

Fossiez, Djossou, Chomarat et al.: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." in: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996 (PubMed).

Huang, Lu, Li et al.: "Occurrence of cGMP/nitric oxide-sensitive store-operated calcium entry in fibroblasts and its effect on matrix metalloproteinase secretion." in: World journal of gastroenterology : WJG, Vol. 12, Issue 34, pp. 5483-9, 2006 (PubMed).

Alternatives for antigen "Interleukin 17A (IL17A)", type "Peptides"
Reactivities (5)
Beacon