Interleukin 17 Receptor B (IL17RB) Peptide

Details for Product No. ABIN493068
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Protein Name
Origin
Human
(2)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 3 references available
Quantity 0.25 mg
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Catalog No. ABIN493068
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Alternative Name IL17RB / IL17BR
Background Pro inflammatory cytokine, IL-17 (IL-17A or CTLA-8) plays a central role in inflammation and autoimmunity. The IL17, like other cytokines is produce by activation of T cell receptor through CD3 cross linking (4). IL-17 is a crucial effecter cytokine, whose production is specifically triggered by IL-23, and it has been shown to be an essential inflammatory mediator in other autoimmune diseases and inflammatory conditions. In human the co-stimulation of T cells thru CD28 several co-stimulatory molecules (ICOS, 4-1BB, CD40L) mildly enhance the IL17 expression where as IL23 profoundly enhance the CD3 induced IL17 expression. The IL-17 expression is also sensitive to cyclosporin-A and MAPK inhibitors, suggesting the involvement of the calcineurin/NFAT and MAPK signaling pathway. IL17 signaling requires its binding to IL17 receptor, IL17 receptor is expression is widespread, the activity of IL17 is most commonly defined by its ability to induce the expression of inflammatory cytokines, chemokines and other mediators by stromal cells. In mouse genetically deficient in IL17RA, the IL17 signaling is poorly compensated by IL17RC suggesting the biological activity of IL17 is dependent on a heteromeric receptor complex composed of IL17RA and IL17RC (2). At least three types of IL17 receptors are cloned and characterized, IL17RA, IL17RB and IL17RC, IL17C is expressed in multiple spliced variant form (IL17RC1, ILRC2, and ILRC3). IL17RA deficient mice also showed high susceptibility and recovery after infusion of IL17A to hemopieotic cytotoxicity to gamma radiation suggesting involvement of IL17R dependent inducible mechanism that is required for recovery of granulopoiesis after radiation injury (3). IL17R is also involvement in allograft rejection and Intragraft IL-17 inhibition may be useful as an adjuvant therapy to systemic immunosuppression in tissue transplantation. The predicted IL17RB receptor (502 aa) is a ubiquitous membrane glycoprotein that specifically binds to IL17B and IL17E but not to IL17 or IL17C. the receptor is known to activate the NF-KappaB and the production of IL8 induced by IL17E. the rat counter part if this receptor is induced during intestinal inflammation, suggesting the immuno-regulatory function of this receptor. The IL17RB is expressed in 2 distinct variant forms. Like other cytokines receptors, IL17RB also has multimeric structure. Interleukin 17B and its receptor play a pathogenic role in many inflammatory and autoimmune diseases including rheumatoid arthritis. The IL17RB has at least 2 TMD that anchor the protein to the cell membrane with a large intrcyctoplasmic domain where protein and signaling molecules interact with the receptor complex.Synonyms: Cytokine receptor CRL4, EVI27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17RB, Interleukin-17 receptor B, Interleukin-17B receptor
Gene ID 55540
NCBI Accession NP_061195
UniProt Q9NRM6
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Antigenic blocking peptide for ABIN493069

Restrictions For Research Use only
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Background publications Fossiez, Djossou, Chomarat et al.: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." in: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996 (PubMed).

Tan, Huang, Zhong et al.: "IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 6186-93, 2006 (PubMed).

Toy, Kugler, Wolfson et al.: "Cutting edge: interleukin 17 signals through a heteromeric receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 36-9, 2006 (PubMed).

Validation Images
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