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phosphodiesterase 4A, CAMP-Specific (PDE4A) Peptide

Details for Product No. ABIN493248
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Protein Name
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 2 references available
Quantity 0.25 mg
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Availability Discontinued
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Catalog No. ABIN493248
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Alternative Name PDE4A
Background Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. In brain more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes (1). PDE4 enzymes are also important molecular targets for variety of therapeutic agents like antidepressants, anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprised of 4 genes (PDE4A, B, C and D), each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants (2). Rolipram, an antidepressant drug, inhibits all the members of PDE4 family in mM concentration range. In rodents, inhibition of PDE4 enzymes attenuated short- and long- term memory impairment produced by scopolamine and MK801 administration (3). Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A and phosphatases (4). Protein-protein interactions and cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization and cAMP-dependent signaling (5). In brain members of the PDE4A, B and D family are associated with GPCRs (adrenergic and dopaminergic) signaling (6, 7), while in testis PDE4A variants are expressed exclusively in primary and secondary germ cells and are believed to be responsible for normal spermatogenesis (8).
Alternate names: 2EL, 5'-cyclic phosphodiesterase 4A, DPDE2, PDE4, PDE46, PDE4A1, PDE4A10, PDE4A11, PDE4A4, PDE4A4B, PDE4A6, PDE4A7, PDE4A8, PDE4A8A, Phosphodiesterase 4A, Phosphodiesterase-4A cAMP-specific, RD1, cAMP-specific 3'
Gene ID 5141
NCBI Accession NP_001104777
UniProt P27815
Research Area Signaling
Comment

Antigenic blocking peptide for ABIN493249

Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Beavo: "Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms." in: Physiological reviews, Vol. 75, Issue 4, pp. 725-48, 1995 (PubMed).

Yarwood, Steele, Scotland et al.: "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14909-17, 1999 (PubMed).

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