|
Characteristics
|
Synonyms: Proto-oncogene C-crk, p38, Adapter molecule crk
|
|
Swiss-Prot
|
P46108
|
|
Description
|
CRK is a member of an adapter protein family that binds to severaltyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homologydomains) and is involved in several signaling pathways, recruiting cytoplasmic proteins inthe vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminalSH2 domain of this protein functions as a positive regulator of transformation whereas theC-terminal SH3 domain functions as a negative regulator of transformation.
|
|
Specificity
|
Phospho-CRK-S41 Antibody Blocking PeptideAdd. Information: Molecular Weight: 1824. 36 Da. This peptide is for use with antibody ABIN358272 only.
|