You are viewing an incomplete version of our website. Please click to reload the website as full version.

V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) Peptide

Details for Product No. ABIN494876, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Protein Name
(9), (8), (7), (7), (7), (2), (1)
Control Peptide (CP)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Specificity Phospho-RAF1-S43 Antibody Blocking Peptide
Purity 100 %
Background Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.Synonyms: C-RAF, RAF proto-oncogene serine/threonine-protein kinase, Raf-1, cRaf
Molecular Weight 1911.4 Da
Gene ID 5894
NCBI Accession NP_002871
UniProt P04049
Research Area Signaling, Kinases/Phosphatases
Application Notes Optimal working dilution should be determined by the investigator.

This peptide is for ABIN358300

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Dasgupta, Sun, Wang et al.: "Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9527-41, 2004 (PubMed).

Ku, Fu, Omary: "Raf-1 activation disrupts its binding to keratins during cell stress." in: The Journal of cell biology, Vol. 166, Issue 4, pp. 479-85, 2004 (PubMed).

Akula, Ford, Whitman et al.: "Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection." in: Oncogene, Vol. 23, Issue 30, pp. 5227-41, 2004 (PubMed).

Rashdan, Fogel, McHenry et al.: "Improved stent characteristics for prophylaxis of post-ERCP pancreatitis." in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Vol. 2, Issue 4, pp. 322-9, 2004 (PubMed).

Goetz, Harmon, ONeil et al.: "STAT5 activation underlies IL7 receptor-dependent B cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 8, pp. 4770-8, 2004 (PubMed).

Catalog No. ABIN494876

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)