Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Peptide

Details for Product No. ABIN494937
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Protein Name
Origin
Human
(1), (1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN494937
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Specificity Phospho-MAP4K4-pS629 Antibody Blocking Peptide
Purity 100 %
Alternative Name MAP4K4
Background M4K4, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.Synonyms: HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEKKK 4, Mitogen-activated protein kinase kinase kinase kinase 4, NIK, Nck-interacting kinase
Molecular Weight 1778.44 Da
Gene ID 9448
NCBI Accession NP_004825
UniProt O95819
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN358366

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL DI water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Ishikawa, Nagase, Suyama et al.: "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 3, pp. 169-76, 1998 (PubMed).

Yao, Zhou, Wang et al.: "A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway." in: The Journal of biological chemistry, Vol. 274, Issue 4, pp. 2118-25, 1999 (PubMed).

Wright, Wang, Manning et al.: "The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion." in: Molecular and cellular biology, Vol. 23, Issue 6, pp. 2068-82, 2003 (PubMed).

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