PDZ Binding Kinase (PBK) Peptide

Details for Product No. ABIN495068
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Protein Name
Control Peptide (CP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN495068
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Specificity Phospho-PBK-pY74 Antibody Blocking Peptide
Purity 100 %
Alternative Name PBK / TOPK
Background PBK is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.Synonyms: CT84, Cancer/testis antigen 84, Lymphokine-activated killer T-cell-originated protein kinase, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, SPK, T-LAK cell-originated protein kinase
Molecular Weight 2335.96 Da
Gene ID 55872
NCBI Accession NP_060962
UniProt Q96KB5
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 0.1 mL DI water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Nandi, Tidwell, Karp et al.: "Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells." in: Blood cells, molecules & diseases, Vol. 32, Issue 1, pp. 240-5, 2004 (PubMed).

Simons-Evelyn, Bailey-Dell, Toretsky et al.: "PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells." in: Blood cells, molecules & diseases, Vol. 27, Issue 5, pp. 825-9, 2002 (PubMed).

Zhao, Dai, Zhao et al.: "PDZ-binding kinase participates in spermatogenesis." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 6, pp. 631-6, 2001 (PubMed).

Abe, Matsumoto, Kito et al.: "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21525-31, 2000 (PubMed).

Gaudet, Branton, Lue: "Characterization of PDZ-binding kinase, a mitotic kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 10, pp. 5167-72, 2000 (PubMed).

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