Sprouty Homolog 4 (SPRY4) Peptide

Details for Product No. ABIN495076
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Protein Name
Origin
Human
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN495076
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Specificity Phospho-SPRY4-pY75 Antibody Blocking Peptide
Purity 100 %
Alternative Name Sprouty Homolog 4 / SPRY4
Background SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.Synonyms: Sprouty 4, Spry-4
Molecular Weight 2056.52 Da
Gene ID 81848
NCBI Accession NP_001120968
UniProt Q9C004
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN358511

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL DI water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Tsumura, Toshima, Leeksma et al.: "Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase." in: The Biochemical journal, Vol. 387, Issue Pt 3, pp. 627-37, 2005 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

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