tyrosine Kinase, Non-Receptor, 2 (TNK2) Peptide

Details for Product No. ABIN495078
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Protein Name
Origin
Human
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 4 references available
Quantity 0.1 mg
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Availability Discontinued
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Catalog No. ABIN495078
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Specificity Phospho-ACK1-pY518 Antibody Blocking Peptide
Purity 100 %
Alternative Name TNK2 / ACK1
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Alternate names: Activated CDC42 kinase 1
Molecular Weight 1673.11 Da
Gene ID 10188
NCBI Accession NP_001010938
UniProt Q07912
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN358513

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Expiry Date 12 months
Background publications Goss, Lee, Moritz et al.: "A common phosphotyrosine signature for the Bcr-Abl kinase." in: Blood, Vol. 107, Issue 12, pp. 4888-97, 2006 (PubMed).

Cohen: "Varicella-zoster vaccine virus: evolution in action." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 1, pp. 7-8, 2007 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

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