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Details for Product No. ABIN495078

tyrosine Kinase, Non-Receptor, 2 (TNK2) Peptide

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Protein Name
Synonyms ACK, ACK-1, ACK1, p21cdc42Hs, AW552477, Ack, Cdgip, Pyk1
Application
Control Peptide (CP)
Pubmed 4 references available
Catalog no. ABIN495078
Quantity 0.1 mg
Price
165.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Specificity Phospho-ACK1-pY518 Antibody Blocking Peptide
Alternative Name TNK2 / ACK1
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Alternate names: Activated CDC42 kinase 1
Molecular Weight 1673.11 Da.
Gene ID 10188
NCBI Accession NP_001010938.1
UniProt Q07912
Comment

This peptide is for ABIN358513

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL DI water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Goss, Lee, Moritz et al.: "A common phosphotyrosine signature for the Bcr-Abl kinase." in: Blood, Vol. 107, Issue 12, pp. 4888-97, 2006 (PubMed).

Cohen: "Varicella-zoster vaccine virus: evolution in action." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 1, pp. 7-8, 2007 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

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