Baculoviral IAP Repeat-Containing 7 (BIRC7) Peptide

Details for Product No. ABIN495136
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Protein Name
Origin
Human
(3), (1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN495136
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Specificity BIRC7 Antibody (C-term) Blocking Peptide
Purity 100 %
Alternative Name BIRC7 / LIVIN
Background BIRC7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
Alternate names: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50
Molecular Weight 1647.37 Da
Gene ID 79444
NCBI Accession NP_071444
UniProt Q96CA5
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN358607

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Expiry Date 12 months
Background publications Kasof, Gomes: "Livin, a novel inhibitor of apoptosis protein family member." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3238-46, 2001 (PubMed).

Vucic, Deshayes, Ackerly et al.: "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)." in: The Journal of biological chemistry, Vol. 277, Issue 14, pp. 12275-9, 2002 (PubMed).

Sanna, da Silva Correia, Ducrey et al.: "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1754-66, 2002 (PubMed).

Gazzaniga, Gradilone, Giuliani et al.: "Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 14, Issue 1, pp. 85-90, 2002 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

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