MLL3 Peptide

Details for Product No. ABIN495172
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Protein Name
Application
Control Peptide (CP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN495172
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Specificity MLL3 Antibody (C-term) Blocking Peptide
Background The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4,911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus, a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region, and 2 C-terminal FY (phe-tyr) motifs and the SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs.
Alternate names: HALR, Histone-lysine N-methyltransferase MLL3, Homologous to ALR protein, KIAA1506, KMT2C, Lysine N-methyltransferase 2C, Myeloid/lymphoid or mixed-lineage leukemia protein 3
Molecular Weight 1822.66 Da.
Gene ID 58508
NCBI Accession NP_733751
UniProt Q8NEZ4
Comment

This peptide is for ABIN358665

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Nagase, Kikuno, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 2, pp. 143-50, 2000 (PubMed).

Tan, Chow: "Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects." in: Cancer detection and prevention, Vol. 25, Issue 5, pp. 454-69, 2001 (PubMed).

Goo, Sohn, Kim et al.: "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 140-9, 2002 (PubMed).

Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

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