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Details for Product No. ABIN495182

Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Peptide

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Protein Name
Synonyms MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, MMP1, AI325305, MT-MMP-1, sabe, Mt1-mmp, mmp-x1, mt1-mmp, mtmmp1
Application
Control Peptide (CP)
Pubmed 4 references available
Catalog no. ABIN495182
Quantity 0.1 mg
Price
165.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Specificity MMP14 Antibody (N-term) Blocking Peptide
Alternative Name MMP-14
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
Alternate names: MMP-X1, MMP14, Matrix metalloproteinase-14, Membrane-type-1 matrix metalloproteinase
Molecular Weight 1977.63 Da.
Gene ID 4323
NCBI Accession NP_004986.1
UniProt P50281
Research Area Cancer, Extracellular Matrix, Inflammation
Comment

This peptide is for ABIN358687

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Will, Hinzmann: "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment." in: European journal of biochemistry / FEBS, Vol. 231, Issue 3, pp. 602-8, 1995 (PubMed).

Okada, Bellocq, Rouyer et al.: "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 2730-4, 1995 (PubMed).

Takino, Sato, Yamamoto et al.: "Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain." in: Gene, Vol. 155, Issue 2, pp. 293-8, 1995 (PubMed).

Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).

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