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2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) Peptide

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Protein Name
(5), (2)
Control Peptide (CP)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Specificity OAS1 Antibody (C-term) Blocking Peptide
Purity 100 %
Background OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.Synonyms: (2-5')oligo(A) synthetase 1, 2'-5'-oligoadenylate synthetase 1, 2-5A synthetase 1, p46/p42 OAS
Molecular Weight 1791.42 Da
Gene ID 4938
NCBI Accession NP_001027581
UniProt P00973
Application Notes Optimal working dilution should be determined by the investigator.

This peptide is for ABIN358716

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Sarkar, Ghosh, Wang et al.: "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases." in: The Journal of biological chemistry, Vol. 274, Issue 36, pp. 25535-42, 1999 (PubMed).

Ghosh, Sarkar, Guo et al.: "Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 33220-6, 1998 (PubMed).

Rutherford, Hannigan, Williams: "Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene." in: The EMBO journal, Vol. 7, Issue 3, pp. 751-9, 1988 (PubMed).

Ghosh, Kusari, Bandyopadhyay et al.: "Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 15293-9, 1991 (PubMed).

Catalog No. ABIN495203

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