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Details for Product No. ABIN495272

Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6) Peptide

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Protein Name
Synonyms ARTD17, PARP-6-B1, PARP-6-C, pART17, 1700119G14Rik, 2310028P13Rik, 3110038K10Rik, C030013N01Rik, PARP-6, RGD1310937
Application
Control Peptide (CP)
Pubmed 1 reference available
Catalog no. ABIN495272
Quantity 0.1 mg
Price
165.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Specificity Parp6 Antibody (C-term) Blocking Peptide
Alternative Name PARP6
Background Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Alternate names: PARP-6, Poly [ADP-ribose] polymerase 6
Molecular Weight 1969.71 Da.
Gene ID 56965
NCBI Accession NP_064599.2
UniProt Q2NL67
Research Area Chromatin and Nuclear Signaling
Comment

This peptide is for ABIN358806

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL DI water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Amé, Spenlehauer, de Murcia: "The PARP superfamily." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 26, Issue 8, pp. 882-93, 2004 (PubMed).

Alternatives for antigen "Poly (ADP-Ribose) Polymerase Family, Member 6 (PARP6)", type "Peptides"
Reactivities (1)
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