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Glutamate Receptor, Metabotropic 5 (GRM5) Peptide
| Name | Glutamate Receptor, Metabotropic 5 (GRM5) |
| Synonyms | mGlu5, GPRC1E, MGLUR5 |
| Catalog no. | ABIN495331 |
| Quantity | 0.1 mg (1,0 mg/ml (after reconstitution)) |
| Price | 145.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Synonyms: Metabotropic glutamate receptor 5, GPRC1E, MGLUR5 |
| Swiss-Prot | P41594 |
| Description | L-glutamate is the major excitatory neurotransmitter in the central nervous system andactivates both ionotropic and metabotropic glutamate receptors. Glutamatergicneurotransmission is involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropic glutamate receptors area family of G protein-coupled receptors, that have been divided into 3 groups on the basisof sequence homology, putative signal transduction mechanisms, and pharmacologicproperties. Group I includes GRM1 and GRM5 (also known as GPRC1E) and these receptorshave been shown to activate phospholipase C. Group II includes GRM2 and GRM3 whileGroup III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked tothe inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activityof GRM5 is mediated by a G-protein that activates a phosphatidylinositol-calcium secondmessenger system and generates a calcium-activated chloride current. |
| Specificity | GPRC1E Antibody (C-term) Blocking PeptideAdd. Information: Molecular Weight: 1827. 33 Da. This peptide is for use with antibody ABIN358930 only. |
Application Details
| Concentration | 1,0 mg/ml (after reconstitution) |
| Storage | Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one monthor (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Restrictions | For Research Use only |
