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Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) Peptide

Details for Product No. ABIN495354
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Protein Name
Application
Control Peptide (CP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN495354
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Specificity PARK2 (Parkin) Antibody (C-term) Blocking Peptide
Alternative Name PARK2 / Parkin
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.
Alternate names: AR-JP, E3 ubiquitin-protein ligase parkin, LPRS2, PDJ, PRKN, Parkinson disease 2, Parkinson juvenile disease protein 2
Molecular Weight 1976.71 Da.
Gene ID 5071
NCBI Accession NP_004553.2
UniProt O60260
Comment

This peptide is for ABIN358990

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Wang, Denison, Lai et al.: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

Yao, Gu, Nakamura et al.: "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10810-4, 2004 (PubMed).

Pigullo, De Luca, Barone et al.: "Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor." in: Parkinsonism & related disorders, Vol. 10, Issue 6, pp. 357-62, 2004 (PubMed).

Kumru, Santamaria, Tolosa et al.: "Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations." in: Annals of neurology, Vol. 56, Issue 4, pp. 599-603, 2004 (PubMed).

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